Independence of proline chemotaxis and transport in Bacillus subtilis

G. W. Ordal, D. P. Villani, R. A. Nicholas, F. G. Hamel

Research output: Contribution to journalArticlepeer-review


Values of K(I) for nine proline analogs as inhibitors of proline chemotaxis and of proline transport were determined. Two of them inhibited transport at substantially lower concentrations than chemotaxis; two at substantially higher concentrations. Moreover, mutants, believed to be in the component that binds proline, were isolated that showed a shift of K(M) for transport to higher concentrations, one as much as 40-fold. However, chemotaxis was virtually unaffected. Therefore, unlike galactose chemotaxis and transport in Escherichia coli, which share the galactose-binding protein proline chemotaxis and transport in B. subtilis are independent.

Original languageEnglish (US)
Pages (from-to)4916-4919
Number of pages4
JournalJournal of Biological Chemistry
Issue number14
StatePublished - 1978

ASJC Scopus subject areas

  • Biochemistry
  • Molecular Biology
  • Cell Biology


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