Increased plasma levels of gut-derived phenolics linked to walking and running following two weeks of flavonoid supplementation

David C. Nieman, Colin D. Kay, Atul S. Rathore, Mary H. Grace, Renee C. Strauch, Ella H. Stephan, Camila A. Sakaguchi, Mary Ann Lila

Research output: Contribution to journalArticle

Abstract

Using a randomized, double-blinded, placebo-controlled, parallel group design, this investigation determined if the combination of two weeks of flavonoid supplementation (329 mg/day, quercetin, anthocyanins, flavan-3-ols mixture) and a 45-minute walking bout (62.2 ± 0.9% VO2max (maximal oxygen consumption rate)) enhanced the translocation of gut-derived phenolics into circulation in a group of walkers (n = 77). The walkers (flavonoid, placebo groups) were randomized to either sit or walk briskly on treadmills for 45 min (thus, four groups: placebo–sit, placebo–walk, flavonoid–sit, flavonoid–walk). A comparator group of runners (n = 19) ingested a double flavonoid dose for two weeks (658 mg/day) and ran for 2.5 h (69.2 ± 1.2% VO2max). Four blood samples were collected (pre-and post-supplementation, immediately post-and 24 h post-exercise/rest). Of the 76 metabolites detected in this targeted analysis, 15 increased after the 2.5 h run, and when grouped were also elevated post-exercise (versus placebo–sit) for the placebo– and flavonoid–walking groups (p < 0.05). A secondary analysis showed that pre-study plasma concentrations of gut-derived phenolics in the runners were 40% higher compared to walkers (p = 0.031). These data indicate that acute exercise bouts (brisk walking, intensive running) are linked to an increased translocation of gut-derived phenolics into circulation, an effect that is amplified when combined with a two-week period of increased flavonoid intake or chronic training as a runner.

Original languageEnglish (US)
Article number1718
JournalNutrients
Volume10
Issue number11
DOIs
StatePublished - Nov 9 2018

Keywords

  • Colon
  • Exercise
  • Hippurate
  • Intestinal tract
  • Metabolite
  • Polyphenol

ASJC Scopus subject areas

  • Food Science
  • Nutrition and Dietetics

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    Nieman, D. C., Kay, C. D., Rathore, A. S., Grace, M. H., Strauch, R. C., Stephan, E. H., Sakaguchi, C. A., & Lila, M. A. (2018). Increased plasma levels of gut-derived phenolics linked to walking and running following two weeks of flavonoid supplementation. Nutrients, 10(11), [1718]. https://doi.org/10.3390/nu10111718