Increase in chemokine CXCL1 by ERβ ligand treatment is a key mediator in promoting axon myelination

Hawra Karim, Sung Hoon Kim, Andrew S. Lapato, Norio Yasui, John A. Katzenellenbogen, Seema K. Tiwari-Woodruff

Research output: Contribution to journalArticlepeer-review

Abstract

Estrogen receptor β (ERβ) ligands promote remyelination in mouse models of multiple sclerosis. Recent work using experimental autoimmune encephalomyelitis (EAE) has shown that ERβ ligands induce axon remyelination, but impact peripheral inflammation to varying degrees. To identify if ERβ ligands initiate a common immune mechanism in remyelination, central and peripheral immunity and pathology in mice given ERβ ligands at peak EAE were assessed. All ERβ ligands induced differential expression of cytokines and chemokines, but increased levels of CXCL1 in the periphery and in astrocytes. Oligodendrocyte CXCR2 binds CXCL1 and has been implicated in normal myelination. In addition, despite extensive immune cell accumulation in the CNS, all ERβ ligands promoted extensive remyelination in mice at peak EAE. This finding highlights a component of the mechanism by which ERβ ligands mediate remyelination. Hence, interplay between the immune system and central nervous system may be responsible for the remyelinating effects of ERβ ligands. Our findings of potential neuroprotective benefits arising from the presence of CXCL1 could have implications for improved therapies for multiple sclerosis.

Original languageEnglish (US)
Pages (from-to)6291-6296
Number of pages6
JournalProceedings of the National Academy of Sciences of the United States of America
Volume115
Issue number24
DOIs
StatePublished - Jun 12 2018

Keywords

  • CXCL1
  • Immunomodulation
  • Multiple sclerosis
  • Oligodendrocytes
  • Remyelination

ASJC Scopus subject areas

  • General

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