Incorporation of Nonproteinogenic Amino Acids in Class i and II Lantibiotics

Nidhi Kakkar, Jessica G. Perez, Wenshe R. Liu, Michael C. Jewett, Wilfred A. Van Der Donk

Research output: Contribution to journalArticlepeer-review


Lantibiotics are ribosomally synthesized and post-translationally modified peptide natural products that contain thioether cross-links formed by lanthionine and methyllanthionine residues. They exert potent antimicrobial activity against Gram-positive bacteria. We herein report production of analogues of two lantibiotics, lacticin 481 and nisin, that contain nonproteinogenic amino acids using two different strategies involving amber stop codon suppression technology. These methods complement recent alternative approaches to incorporate nonproteinogenic amino acids into lantibiotics.

Original languageEnglish (US)
Pages (from-to)951-957
Number of pages7
JournalACS chemical biology
Issue number4
StatePublished - Apr 20 2018

ASJC Scopus subject areas

  • Biochemistry
  • Molecular Medicine


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