That both genetic (nature) and environmental (nurture) factors contribute to the aetiology of depression and other common mental disorders is well recognised. However, the study of gene-environment interaction (G × E) in mental disorders has recently incited a great deal of controversy. We have suggested (1) that what is needed is more, and better quality, rather than less, research on how genotypes and a range of environmental factors jointly produce mental disorders. In particular, we believe that the non-replication of genetic main effects and G × E in mental disorders may be explained at least in part by the lack of consideration of relevant social environmental contexts.
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