Incorporating the social environment in genotype environment interaction studies of mental disorders

K. C. Koenen, M. Uddin, A. B. Amstadter, S. Galea

Research output: Contribution to journalReview articlepeer-review

Abstract

That both genetic (nature) and environmental (nurture) factors contribute to the aetiology of depression and other common mental disorders is well recognised. However, the study of gene-environment interaction (G × E) in mental disorders has recently incited a great deal of controversy. We have suggested (1) that what is needed is more, and better quality, rather than less, research on how genotypes and a range of environmental factors jointly produce mental disorders. In particular, we believe that the non-replication of genetic main effects and G × E in mental disorders may be explained at least in part by the lack of consideration of relevant social environmental contexts.

Original languageEnglish (US)
Pages (from-to)1489-1492
Number of pages4
JournalInternational Journal of Clinical Practice
Volume64
Issue number11
DOIs
StatePublished - Oct 2010

ASJC Scopus subject areas

  • Medicine(all)

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