Incorporating DNA Methyltransferase Inhibitors (DNMTis) in the Treatment of Genitourinary Malignancies: A Systematic Review

Michal Chovanec, Fadi Taza, Maitri Kalra, Noah Hahn, Kenneth P. Nephew, Michael J Spinella, Costantine Albany

Research output: Contribution to journalReview article

Abstract

Inhibition of DNA methyltransferases (DNMTs) has emerged as a novel treatment strategy in solid tumors. Aberrant hypermethylation in promoters of critical tumor suppressor genes is the basis for the idea that treatment with hypomethylating agents may lead to the restoration of a “normal” epigenome and produce clinically meaningful therapeutic outcomes. The aim of this review article is to summarize the current state of knowledge of DNMT inhibitors in the treatment of genitourinary malignancies. The efficacy of these agents in genitourinary malignancies was reported in a number of studies and suggests a role of induced DNA hypomethylation in overcoming resistance to conventional cytotoxic treatments. The clinical significance of these findings should be further investigated.

Original languageEnglish (US)
Pages (from-to)49-60
Number of pages12
JournalTargeted Oncology
Volume13
Issue number1
DOIs
StatePublished - Feb 1 2018

Fingerprint

Methyltransferases
DNA
Neoplasms
Tumor Suppressor Genes
Therapeutics

ASJC Scopus subject areas

  • Oncology
  • Cancer Research
  • Pharmacology (medical)

Cite this

Incorporating DNA Methyltransferase Inhibitors (DNMTis) in the Treatment of Genitourinary Malignancies : A Systematic Review. / Chovanec, Michal; Taza, Fadi; Kalra, Maitri; Hahn, Noah; Nephew, Kenneth P.; Spinella, Michael J; Albany, Costantine.

In: Targeted Oncology, Vol. 13, No. 1, 01.02.2018, p. 49-60.

Research output: Contribution to journalReview article

Chovanec, Michal ; Taza, Fadi ; Kalra, Maitri ; Hahn, Noah ; Nephew, Kenneth P. ; Spinella, Michael J ; Albany, Costantine. / Incorporating DNA Methyltransferase Inhibitors (DNMTis) in the Treatment of Genitourinary Malignancies : A Systematic Review. In: Targeted Oncology. 2018 ; Vol. 13, No. 1. pp. 49-60.
@article{eb505e75a95c429d931419c554478a58,
title = "Incorporating DNA Methyltransferase Inhibitors (DNMTis) in the Treatment of Genitourinary Malignancies: A Systematic Review",
abstract = "Inhibition of DNA methyltransferases (DNMTs) has emerged as a novel treatment strategy in solid tumors. Aberrant hypermethylation in promoters of critical tumor suppressor genes is the basis for the idea that treatment with hypomethylating agents may lead to the restoration of a “normal” epigenome and produce clinically meaningful therapeutic outcomes. The aim of this review article is to summarize the current state of knowledge of DNMT inhibitors in the treatment of genitourinary malignancies. The efficacy of these agents in genitourinary malignancies was reported in a number of studies and suggests a role of induced DNA hypomethylation in overcoming resistance to conventional cytotoxic treatments. The clinical significance of these findings should be further investigated.",
author = "Michal Chovanec and Fadi Taza and Maitri Kalra and Noah Hahn and Nephew, {Kenneth P.} and Spinella, {Michael J} and Costantine Albany",
year = "2018",
month = "2",
day = "1",
doi = "10.1007/s11523-017-0546-x",
language = "English (US)",
volume = "13",
pages = "49--60",
journal = "Targeted Oncology",
issn = "1776-2596",
publisher = "Springer Paris",
number = "1",

}

TY - JOUR

T1 - Incorporating DNA Methyltransferase Inhibitors (DNMTis) in the Treatment of Genitourinary Malignancies

T2 - A Systematic Review

AU - Chovanec, Michal

AU - Taza, Fadi

AU - Kalra, Maitri

AU - Hahn, Noah

AU - Nephew, Kenneth P.

AU - Spinella, Michael J

AU - Albany, Costantine

PY - 2018/2/1

Y1 - 2018/2/1

N2 - Inhibition of DNA methyltransferases (DNMTs) has emerged as a novel treatment strategy in solid tumors. Aberrant hypermethylation in promoters of critical tumor suppressor genes is the basis for the idea that treatment with hypomethylating agents may lead to the restoration of a “normal” epigenome and produce clinically meaningful therapeutic outcomes. The aim of this review article is to summarize the current state of knowledge of DNMT inhibitors in the treatment of genitourinary malignancies. The efficacy of these agents in genitourinary malignancies was reported in a number of studies and suggests a role of induced DNA hypomethylation in overcoming resistance to conventional cytotoxic treatments. The clinical significance of these findings should be further investigated.

AB - Inhibition of DNA methyltransferases (DNMTs) has emerged as a novel treatment strategy in solid tumors. Aberrant hypermethylation in promoters of critical tumor suppressor genes is the basis for the idea that treatment with hypomethylating agents may lead to the restoration of a “normal” epigenome and produce clinically meaningful therapeutic outcomes. The aim of this review article is to summarize the current state of knowledge of DNMT inhibitors in the treatment of genitourinary malignancies. The efficacy of these agents in genitourinary malignancies was reported in a number of studies and suggests a role of induced DNA hypomethylation in overcoming resistance to conventional cytotoxic treatments. The clinical significance of these findings should be further investigated.

UR - http://www.scopus.com/inward/record.url?scp=85037688404&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=85037688404&partnerID=8YFLogxK

U2 - 10.1007/s11523-017-0546-x

DO - 10.1007/s11523-017-0546-x

M3 - Review article

C2 - 29230671

AN - SCOPUS:85037688404

VL - 13

SP - 49

EP - 60

JO - Targeted Oncology

JF - Targeted Oncology

SN - 1776-2596

IS - 1

ER -