TY - JOUR
T1 - Income and markers of immunological cellular aging
AU - Aiello, Allison E.
AU - Feinstein, Lydia
AU - Dowd, Jennifer B.
AU - Pawelec, Graham
AU - Derhovanessian, Evelyna
AU - Galea, Sandro
AU - Uddin, Monica
AU - Wildman, Derek E.
AU - Simanek, Amanda M.
N1 - Funding Information:
Source of Funding and Conflicts of Interest: Lydia Feinstein and Allison Aiello were supported by the Population Research Infrastructure Program (P2C HD050924) awarded to the Carolina Population Center at The University of North Carolina at Chapel Hill by the Eunice Kennedy Shriver National Institute of Child Health and Human Development. Lydia Feinstein was supported by the Population Research Training grant (T32 HD007168) awarded to the Carolina Population Center at The University of North Carolina at Chapel Hill by the Eunice Kennedy Shriver National Institute of Child Health and Human Development. The Detroit Neighborhood Health Study, which provided data for this secondary analysis, was funded by the National Institutes of Health (Grant Nos. DA22720 [DNHS], DA022720-S1 [DNHS PhenX], and RC1MH088283 [DNHS Epigenetics]) to PI Aiello. The funders had no role in study design, data collection and analysis, decision to publish, or preparation of the manuscript. The authors report no conflicts of interest and no source of funding.
Publisher Copyright:
© 2016 by the American Psychosomatic Society.
PY - 2016/7/1
Y1 - 2016/7/1
N2 - Objective Socioeconomic disadvantage may contribute to poor health through immune-related biological mechanisms. We examined the associations between socioeconomic status, as measured by annual household income, and T-cell markers of aging, including the ratios of CD4 and CD8 effector cells to naïve cells (E/N ratio) and the CD4/CD8 T-cell ratio. We hypothesized that participants with a lower income would have higher E/N ratios and lower CD4/CD8 ratios compared with participants with a higher income, and that these associations would be partially mediated by elevated cytomegalovirus (CMV) IgG antibody levels, a virus implicated in aging and clonal expansion of T cells. Methods Data were from 79 individuals who participated in the population-based Detroit Neighborhood Health Study. We used linear regression to quantify the association between a $10,000 decrease in income and each ratio outcome. Results After adjustment for age, sex, race, smoking, medication use, and lifetime history of mental health conditions, lower income was associated with a 0.41 (95% confidence interval = 0.09-0.72) log-unit increase in the CD4 E/N ratio and a 0.20 (95% confidence interval = 0.02-0.39) log-unit increase in the CD8 E/N ratio. CMV immunoglobulin G antibody level partially mediated these associations. Conclusions Our study suggests that low socioeconomic status is associated with immunological aging as measured by the E/N ratio and that impaired immune control of CMV may partially mediate these associations.
AB - Objective Socioeconomic disadvantage may contribute to poor health through immune-related biological mechanisms. We examined the associations between socioeconomic status, as measured by annual household income, and T-cell markers of aging, including the ratios of CD4 and CD8 effector cells to naïve cells (E/N ratio) and the CD4/CD8 T-cell ratio. We hypothesized that participants with a lower income would have higher E/N ratios and lower CD4/CD8 ratios compared with participants with a higher income, and that these associations would be partially mediated by elevated cytomegalovirus (CMV) IgG antibody levels, a virus implicated in aging and clonal expansion of T cells. Methods Data were from 79 individuals who participated in the population-based Detroit Neighborhood Health Study. We used linear regression to quantify the association between a $10,000 decrease in income and each ratio outcome. Results After adjustment for age, sex, race, smoking, medication use, and lifetime history of mental health conditions, lower income was associated with a 0.41 (95% confidence interval = 0.09-0.72) log-unit increase in the CD4 E/N ratio and a 0.20 (95% confidence interval = 0.02-0.39) log-unit increase in the CD8 E/N ratio. CMV immunoglobulin G antibody level partially mediated these associations. Conclusions Our study suggests that low socioeconomic status is associated with immunological aging as measured by the E/N ratio and that impaired immune control of CMV may partially mediate these associations.
KW - Detroit Neighborhood Health Study
KW - aging
KW - cytomegalovirus
KW - immunity
KW - immunosenescence
KW - socioeconomic status
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U2 - 10.1097/PSY.0000000000000320
DO - 10.1097/PSY.0000000000000320
M3 - Article
C2 - 27187853
AN - SCOPUS:84969157868
VL - 78
SP - 657
EP - 666
JO - Psychosomatic Medicine
JF - Psychosomatic Medicine
SN - 0033-3174
IS - 6
ER -