In vivo target-specific delivery of macromolecular agents with MR- guided focused ultrasound

Mark D. Bednarski; James W. Lee; Matthew R. Callstrom; King C.P. Li

doi:10.1148/radiology.204.1.9205257

In vivo target-specific delivery of macromolecular agents with MR- guided focused ultrasound

Mark D. Bednarski, James W. Lee, Matthew R. Callstrom, King C.P. Li

Research output: Contribution to journal › Article › peer-review

Abstract

Magnetic resonance (MR) images in rabbit muscle were used to select a target region for application of pulsed-focused ultrasound. Liposomes encapsulating gadopentetate dimeglumine, an MR-detectable model representing pharmaceutical agents, were then injected intravenously. Focal enhancement on T1-weighted images, representing gadolinium-liposome accumulation, occurred in the pulsed-focused-ultrasound focal zone. Therefore, MR-guided pulsed- focused ultrasound targeted the delivery of macromolecular pharmaceutical agents within tissues.

Original language	English (US)
Pages (from-to)	263-268
Number of pages	6
Journal	Radiology
Volume	204
Issue number	1
DOIs	https://doi.org/10.1148/radiology.204.1.9205257
State	Published - Jul 1997
Externally published	Yes

Keywords

Gadolinium
Magnetic resonance (MR), guidance
Ultrasound (US), focused
Ultrasound (US), technology, Ultrasound (US), therapeutic

ASJC Scopus subject areas

Radiology Nuclear Medicine and imaging

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10.1148/radiology.204.1.9205257

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abstract = "Magnetic resonance (MR) images in rabbit muscle were used to select a target region for application of pulsed-focused ultrasound. Liposomes encapsulating gadopentetate dimeglumine, an MR-detectable model representing pharmaceutical agents, were then injected intravenously. Focal enhancement on T1-weighted images, representing gadolinium-liposome accumulation, occurred in the pulsed-focused-ultrasound focal zone. Therefore, MR-guided pulsed- focused ultrasound targeted the delivery of macromolecular pharmaceutical agents within tissues.",

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year = "1997",

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AU - Li, King C.P.

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N2 - Magnetic resonance (MR) images in rabbit muscle were used to select a target region for application of pulsed-focused ultrasound. Liposomes encapsulating gadopentetate dimeglumine, an MR-detectable model representing pharmaceutical agents, were then injected intravenously. Focal enhancement on T1-weighted images, representing gadolinium-liposome accumulation, occurred in the pulsed-focused-ultrasound focal zone. Therefore, MR-guided pulsed- focused ultrasound targeted the delivery of macromolecular pharmaceutical agents within tissues.

AB - Magnetic resonance (MR) images in rabbit muscle were used to select a target region for application of pulsed-focused ultrasound. Liposomes encapsulating gadopentetate dimeglumine, an MR-detectable model representing pharmaceutical agents, were then injected intravenously. Focal enhancement on T1-weighted images, representing gadolinium-liposome accumulation, occurred in the pulsed-focused-ultrasound focal zone. Therefore, MR-guided pulsed- focused ultrasound targeted the delivery of macromolecular pharmaceutical agents within tissues.

KW - Gadolinium

KW - Magnetic resonance (MR), guidance

KW - Ultrasound (US), focused

KW - Ultrasound (US), technology, Ultrasound (US), therapeutic

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In vivo target-specific delivery of macromolecular agents with MR- guided focused ultrasound

Abstract

Keywords

ASJC Scopus subject areas

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