In-vivo study of quantitative ultrasound parameters in fatty rabbit livers

Trong Nguyen, Anthony Podkowa, Rita Miller, Minh Do, Michael Oelze

Research output: Chapter in Book/Report/Conference proceedingConference contribution


Nonalcoholic fatty liver disease (NAFLD) is the most common cause of chronic liver disease and can often lead to fibrosis, cirrhosis, cancer and complete liver failure. Liver biopsy is the current standard of care to quantify hepatic steatosis but it comes with increased patient risk and only samples a small portion of the liver. Imaging approaches to assess NAFLD include proton density fat fraction (PDFF) estimated via MRI and shear wave elastography. However, MRI is expensive and shear wave elastography is not sensitive to fat content of the liver. On the other hand, ultrasonic attenuation and the backscatter coefficient (BSC) have been observed to be sensitive to levels of fat in the liver. Ultrasound evaluation offers low risk to the patient and the ability to examine the majority of the liver, as compared to liver biopsy. Therefore, a need exists to further develop ultrasonic-based techniques to quantify hepatic steatosis. In this study we explored the use of attenuation and a principal component analysis (PCA) of the BSC to detect and quantify hepatic steatosis in vivo in a rabbit model of fatty liver.

Original languageEnglish (US)
Title of host publication2017 IEEE International Ultrasonics Symposium, IUS 2017
PublisherIEEE Computer Society
ISBN (Electronic)9781538633830
StatePublished - Oct 31 2017
Event2017 IEEE International Ultrasonics Symposium, IUS 2017 - Washington, United States
Duration: Sep 6 2017Sep 9 2017

Publication series

NameIEEE International Ultrasonics Symposium, IUS
ISSN (Print)1948-5719
ISSN (Electronic)1948-5727


Other2017 IEEE International Ultrasonics Symposium, IUS 2017
Country/TerritoryUnited States

ASJC Scopus subject areas

  • Acoustics and Ultrasonics


Dive into the research topics of 'In-vivo study of quantitative ultrasound parameters in fatty rabbit livers'. Together they form a unique fingerprint.

Cite this