In Vivo Multiparametric Ultrasound Imaging of Structural and Functional Tumor Modifications during Therapy

Alexandre Dizeux, Thomas Payen, Delphine Le Guillou-Buffello, Eva Comperat, Jean Luc Gennisson, Mickael Tanter, Michael Oelze, S. Lori Bridal

Research output: Contribution to journalArticle

Abstract

Longitudinal imaging techniques are needed that can meaningfully probe the tumor microenvironment and its spatial heterogeneity. Contrast-enhanced ultrasound, shear wave elastography and quantitative ultrasound are ultrasound-based techniques that provide information on the vascular function and micro-/macroscopic tissue structure. Modifications of the tumor microenvironment induced by cytotoxic and anti-angiogenic molecules in ectopic murine Lewis lung carcinoma tumors were monitored. The most heterogenous structures were found in tumors treated with anti-angiogenic drug that simultaneously accumulated the highest levels of necrosis and fibrosis. The anti-angiogenic group presented the highest number of correlations between parameters related to vascular function and those related to the micro-/macrostructure of the tumor microenvironment. Results suggest how patterns of multiparametric ultrasound modifications can be related to provide a more insightful marker of changes occurring within tumors during therapy.

Original languageEnglish (US)
Pages (from-to)2000-2012
Number of pages13
JournalUltrasound in Medicine and Biology
Volume43
Issue number9
DOIs
StatePublished - Sep 2017

    Fingerprint

Keywords

  • Angiogenesis
  • Elastography
  • Multiparametric imaging
  • Tumor
  • Ultrasound

ASJC Scopus subject areas

  • Biophysics
  • Radiological and Ultrasound Technology
  • Acoustics and Ultrasonics

Cite this

Dizeux, A., Payen, T., Le Guillou-Buffello, D., Comperat, E., Gennisson, J. L., Tanter, M., Oelze, M., & Bridal, S. L. (2017). In Vivo Multiparametric Ultrasound Imaging of Structural and Functional Tumor Modifications during Therapy. Ultrasound in Medicine and Biology, 43(9), 2000-2012. https://doi.org/10.1016/j.ultrasmedbio.2017.03.021