In vivo MR evaluation of Gd-DTPA conjugated to dextran in normal rabbits

King C.P. Li, Ronald G. Quisling, Francis E. Armitage, David Richardson, Christopher Mladinich

Research output: Contribution to journalArticle

Abstract

A dextran-Gd-DTPA compound has been recently synthesized utilizing 70,800 Da molecular weight dextran. This polymeric contrast agent for magnetic resonance imaging has been found chemically to be very stable and to demonstrate in vitro improved relaxivities of 1.5 to 2.3 times that of monomeric Gd-DTPA at 100 MHz. This MR experiment examines the in vivo distribution and relaxivity of the 70,800 Da molecular weight dextran-Gd-DTPA compound in a rabbit model by measuring the change in signal-to-noise ratio of a variety of organs (renal cortex, renal medulla, liver, brain, and torcula herophile) compared to the preinjection state. Results demonstrate prolonged (beyond 60 min) enhancement of the renal cortex, renal medulla, liver and torcula, and no enhancement of brain parenchyma.

Original languageEnglish (US)
Pages (from-to)439-444
Number of pages6
JournalMagnetic Resonance Imaging
Volume10
Issue number3
DOIs
StatePublished - 1992
Externally publishedYes

Keywords

  • Gadolinium
  • MR-contrast media
  • MR-experimental

ASJC Scopus subject areas

  • Biophysics
  • Biomedical Engineering
  • Radiology Nuclear Medicine and imaging

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