@article{7dd46e2c87d74a9a8a66da1dce0b32d6,
title = "In vivo dynamic characterization of the human tympanic membrane using pneumatic optical coherence tomography",
abstract = "Decreased mobility of the human eardrum, the tympanic membrane (TM), is an essential indicator of a prevalent middle ear infection. The current diagnostic method to assess TM mobility is via pneumatic otoscopy, which provides subjective and qualitative information of subtle motion. In this study, a handheld spectral-domain pneumatic optical coherence tomography system was developed to simultaneously measure the displacement of the TM, air pressure inputs applied to a sealed ear canal, and to perform digital pneumatic otoscopy. A novel approach based on quantitative parameters is presented to characterize spatial and temporal variations of the dynamic TM motion. Furthermore, the TM motions of normal middle ears are compared with those of ears with middle ear infections. The capability of noninvasively measuring the rapid motion of the TM is beneficial to understand the complex dynamics of the human TM, and can ultimately lead to improved diagnosis and management of middle ear infections.",
keywords = "biomechanics, optical coherence tomography, otitis media, tympanic membrane, viscoelasticity",
author = "Jungeun Won and Porter, {Ryan G.} and Novak, {Michael A.} and Jon Youakim and Ada Sum and Ronit Barkalifa and Edita Aksamitiene and Anqi Zhang and Ryan Nolan and Ryan Shelton and Boppart, {Stephen A.}",
note = "Funding Information: The authors thank Paula Bradley, Ali Moll, MaryEllen Sherwood, Lindsay Stiger and Adam Wright from the Carle Research Office at Carle Foundation Hospital, Urbana, Illinois, for their help with IRB protocol management and subject consenting and assenting. The authors acknowledge Dr. Neena Tripathy, Dr. Anna Ziemer, Dr. Christine M. Chu, Dr. Kathleen K. Buetow and the nursing staff in the Department of Pediatrics, as well as physician assistants Laura A. Browning and Brent Pearman and the nursing staff in the Department of Otolaryngology at Carle Foundation Hospital for their help in subject recruitment and clinical assistance. Finally, the authors thank Pin‐Chieh Huang at the Beckman Institute for Advanced Science and Technology for valuable discussions on biomechanics and elastography. This research was funded in part by a Bioengineering Research Partnership grant from the National Institute for Biomedical Imaging and Bioengineering at the National Institutes of Health (NIH/NIBIB R01EB013723 and R01EB028615 S.A.B.), and in part by the McGinnis Medical Innovation Fellowship program. Additional information can be found at http://biophotonics.illinois.edu . Publisher Copyright: {\textcopyright} 2020 Wiley-VCH GmbH",
year = "2021",
month = apr,
doi = "10.1002/jbio.202000215",
language = "English (US)",
volume = "14",
journal = "Journal of Biophotonics",
issn = "1864-063X",
publisher = "Wiley-VCH",
number = "4",
}