In-Vivo Catheter-Based Imaging with Optical Coherence Tomography

Costas Pitris, Parth Patwari, Stephen A. Boppart, Brett E. Bouma, Gary J. Tearney, James G. Fujimoto, Mark E. Brezinski

Research output: Chapter in Book/Report/Conference proceedingConference contribution


The high incidence and mortality rate associated with complications resulting from coronary artery atherosclerosis dictate an important and immediate need for a new, high resolution, diagnostic imaging technology that would allow characterization of artery microstructure with a micron scale resolution. OCT allows catheter based, cross-sectional imaging of blood vessels with a 10-20 µm resolution and is ideally suited for in vivo imaging of arterial structure. Recently, OCT imaging was extended to in vitro pathology, including multiple studies on atherosclerotic arteries. OCT has also been directly compared with a 30 MHz, IVUS transducer. In addition to qualitatively superior resolution with respect to imaging plaque, OCT was demonstrated to be quantitatively superior. In vivo imaging was performed on normal, New Zealand White rabbits using a novel rapid data acquisition system which allows imaging at 4 frames per second. This work, focusing on dynamic changes, demonstrates that high resolution intravascular imaging can be performed in vivo using optical coherence tomography. Images at 10 µm resolution were obtained, representing an improvement of over lOX that of 'state of the art' IVUS transducers.

Original languageEnglish (US)
Title of host publicationAdvances in Optical Imaging and Photon Migration, AOIPM 1998
PublisherOptica Publishing Group (formerly OSA)
Number of pages4
ISBN (Electronic)1557525463
StatePublished - 1998
Externally publishedYes
EventAdvances in Optical Imaging and Photon Migration, AOIPM 1998 - Orlando, United States
Duration: Mar 8 1998 → …

Publication series

NameOptics InfoBase Conference Papers
ISSN (Electronic)2162-2701


ConferenceAdvances in Optical Imaging and Photon Migration, AOIPM 1998
Country/TerritoryUnited States
Period3/8/98 → …


  • (170.4500) Optical coherence tomography
  • (170.4580) Optical diagnostics for medicine
  • (170.7180) Ultrasound diagnostics

ASJC Scopus subject areas

  • Electronic, Optical and Magnetic Materials
  • Mechanics of Materials


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