In vivo cancer targeting via glycopolyester nanoparticle mediated metabolic cell labeling followed by click reaction

Hua Wang, Yang Bo, Yang Liu, Ming Xu, Kaimin Cai, Ruibo Wang, Jianjun Cheng

Research output: Contribution to journalArticle

Abstract

We developed glycopolyesters (GPs) via azido-sugar initiated ring-opening polymerization of O-carboxyanhydrides (OCAs) and achieved efficient in vivo cancer targeting via GP-nanoparticle (GP-NP) mediated metabolic cell labeling followed by Click reaction. GP-NP shows controlled release of azido-sugars and can efficiently label LS174T colon cancer cells with azido groups in tumor-bearing mice. The exogenously introduced azido groups render excellent in vivo cancer targeting and retention of dibenzocyclooctyne-Cy5 (DBCO-Cy5) with an increasing tumor retention enhancement over time (68% at 6 h, 105% at 24 h, and 191% at 48 h) compared to control mice without azido labeling. The tumor accumulation of DBCO-doxorubicin is also significantly enhanced in GP-NP pretreated mice, resulting in improved in vivo anticancer efficacy. This study, for the first time, proposes the use of azido-sugar initiated polymerization of OCAs to form sugar delivery vehicles with high stability and controlled release, and demonstrates the increasing tumor targeting effect of DBCO-cargo over time by azido-modified tumor cells.

Original languageEnglish (US)
Article number119305
JournalBiomaterials
Volume218
DOIs
StatePublished - Oct 2019

Fingerprint

Nanoparticles
Labeling
Tumors
Sugars
Neoplasms
Bearings (structural)
Cells
Polymerization
Ring opening polymerization
Doxorubicin
Labels
Colonic Neoplasms

Keywords

  • Cancer targeting
  • Cell labeling
  • Click chemistry
  • Drug design
  • Sugar

ASJC Scopus subject areas

  • Bioengineering
  • Ceramics and Composites
  • Biophysics
  • Biomaterials
  • Mechanics of Materials

Cite this

In vivo cancer targeting via glycopolyester nanoparticle mediated metabolic cell labeling followed by click reaction. / Wang, Hua; Bo, Yang; Liu, Yang; Xu, Ming; Cai, Kaimin; Wang, Ruibo; Cheng, Jianjun.

In: Biomaterials, Vol. 218, 119305, 10.2019.

Research output: Contribution to journalArticle

Wang, Hua ; Bo, Yang ; Liu, Yang ; Xu, Ming ; Cai, Kaimin ; Wang, Ruibo ; Cheng, Jianjun. / In vivo cancer targeting via glycopolyester nanoparticle mediated metabolic cell labeling followed by click reaction. In: Biomaterials. 2019 ; Vol. 218.
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