In vivo biodetection using surface-enhanced raman spectroscopy

Seunghyun Lee, Ulhas S. Kadam, Ana Paula Craig, Joseph Irudayaraj

Research output: Chapter in Book/Report/Conference proceedingChapter


Nanophotonics engages with light-material interaction behaviors that occur on wavelength or subwavelength scales, where the electromagnetic field is confined to the surface of designed nanostructures with unique and tunable optical properties. In particular, “plasmonics” using surface plasmon polaritons (SPPs), simply called surface plasmon, is diverse and a rapidly growing field in nanophotonics. Over the recent decades, the emergence of novel nanomaterials and fabrication of diverse nanostructures on surfaces allow the manipulation of their optical properties as well as develop a methodology to increase inherent sensitivity that lead to new insights at this highly interdisciplinary field for many applications. The confinement of the SPPs is empowered to enhance the electromagnetic field at the interfacial surface that gives rise to remarkable sensitivity to surface conditions and environment surrounding the media refractive index, which is widely employed for biological and chemical sensing. In addition, the enhancement contributes to surface optical properties such as Raman scattering.

Original languageEnglish (US)
Title of host publicationBiosensors Based on Nanomaterials and Nanodevices
EditorsJun Li, Nianqiang Wu
PublisherCRC Press
Number of pages22
ISBN (Electronic)9781466551527
ISBN (Print)9781466551510
StatePublished - Jan 1 2017
Externally publishedYes

ASJC Scopus subject areas

  • General Medicine
  • General Biochemistry, Genetics and Molecular Biology
  • General Engineering
  • General Materials Science
  • General Physics and Astronomy


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