In vivo activities of farnesyl pyrophosphate synthase inhibitors against Leishmania donovani and Toxoplasma gondii

Vanessa Yardley; Anis A. Khan; Michael B. Martin; Teri R. Slifer; Fausto G. Araujo; Silvia N.J. Moreno; Roberto Docampo; Simon L. Croft; Eric Oldfield

doi:10.1128/AAC.46.3.929-931.2002

In vivo activities of farnesyl pyrophosphate synthase inhibitors against Leishmania donovani and Toxoplasma gondii

Vanessa Yardley, Anis A. Khan, Michael B. Martin, Teri R. Slifer, Fausto G. Araujo, Silvia N.J. Moreno, Roberto Docampo, Simon L. Croft, Eric Oldfield

Chemistry

Research output: Contribution to journal › Article › peer-review

Abstract

The in vivo activities of three bisphosphonates were determined against Leishmania donovani and Toxoplasma gondii. Alendronate was essentially inactive against both parasites. Pamidronate was active against L. donovani by intravenous administration. Risedronate had a 50% effective dosage of five 2.6-mg/kg of body weight intraperitoneal doses against L. donovani-infected mice but was less effective against T. gondii-infected mice.

Original language	English (US)
Pages (from-to)	929-931
Number of pages	3
Journal	Antimicrobial Agents and Chemotherapy
Volume	46
Issue number	3
DOIs	https://doi.org/10.1128/AAC.46.3.929-931.2002
State	Published - 2002

ASJC Scopus subject areas

Pharmacology
Pharmacology (medical)
Infectious Diseases

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10.1128/AAC.46.3.929-931.2002

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title = "In vivo activities of farnesyl pyrophosphate synthase inhibitors against Leishmania donovani and Toxoplasma gondii",

abstract = "The in vivo activities of three bisphosphonates were determined against Leishmania donovani and Toxoplasma gondii. Alendronate was essentially inactive against both parasites. Pamidronate was active against L. donovani by intravenous administration. Risedronate had a 50% effective dosage of five 2.6-mg/kg of body weight intraperitoneal doses against L. donovani-infected mice but was less effective against T. gondii-infected mice.",

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T1 - In vivo activities of farnesyl pyrophosphate synthase inhibitors against Leishmania donovani and Toxoplasma gondii

AU - Yardley, Vanessa

AU - Khan, Anis A.

AU - Martin, Michael B.

AU - Slifer, Teri R.

AU - Araujo, Fausto G.

AU - Moreno, Silvia N.J.

AU - Docampo, Roberto

AU - Croft, Simon L.

AU - Oldfield, Eric

PY - 2002

Y1 - 2002

N2 - The in vivo activities of three bisphosphonates were determined against Leishmania donovani and Toxoplasma gondii. Alendronate was essentially inactive against both parasites. Pamidronate was active against L. donovani by intravenous administration. Risedronate had a 50% effective dosage of five 2.6-mg/kg of body weight intraperitoneal doses against L. donovani-infected mice but was less effective against T. gondii-infected mice.

AB - The in vivo activities of three bisphosphonates were determined against Leishmania donovani and Toxoplasma gondii. Alendronate was essentially inactive against both parasites. Pamidronate was active against L. donovani by intravenous administration. Risedronate had a 50% effective dosage of five 2.6-mg/kg of body weight intraperitoneal doses against L. donovani-infected mice but was less effective against T. gondii-infected mice.

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AN - SCOPUS:0036171419

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In vivo activities of farnesyl pyrophosphate synthase inhibitors against Leishmania donovani and Toxoplasma gondii

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