Abstract
The in vivo activities of three bisphosphonates were determined against Leishmania donovani and Toxoplasma gondii. Alendronate was essentially inactive against both parasites. Pamidronate was active against L. donovani by intravenous administration. Risedronate had a 50% effective dosage of five 2.6-mg/kg of body weight intraperitoneal doses against L. donovani-infected mice but was less effective against T. gondii-infected mice.
Original language | English (US) |
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Pages (from-to) | 929-931 |
Number of pages | 3 |
Journal | Antimicrobial Agents and Chemotherapy |
Volume | 46 |
Issue number | 3 |
DOIs | |
State | Published - 2002 |
ASJC Scopus subject areas
- Pharmacology
- Pharmacology (medical)
- Infectious Diseases