In vitro increase of mean corpuscular volume difference (dMCV) as a marker for serum hypertonicity in dogs

Jennifer M. Reinhart, Misty R. Yancey, Lisa M. Pohlman, Thomas Schermerhorn

Research output: Contribution to journalArticlepeer-review

Abstract

Spurious increase in erythrocyte mean corpuscular volume (MCV) on automated cell analyzers is a well-characterized lab error in hypertonic patients. A difference between automated and manual MCV (dMCV) greater than 2 fl has been shown to predict hypertonicity in humans. The purpose of this study was to investigate dMCV as a marker for serum hypertonicity in dogs and to examine the relationship between dMCV and three methods of estimating serum tonicity: measured (OsMM), calculated (OsMC), and calculated effective (OsMCE) osmolalities. OsMC, OsMCE, and dMCV were calculated from routine blood values and OsMM was directly measured in 121 dogs. The dMCV of hypertonic dogs was significantly larger than that of normotonic dogs for all three osmolality methods. dMCV predicted hypertonicity as estimated by OsMM better than it predicted hypertonicity as estimated by OsMC and OsMCE. A cutoff of 2.96 fl yielded the best sensitivity (76%) and specificity (71%) for hypertonicity estimated by OsMM.

Original languageEnglish (US)
Pages (from-to)442-446
Number of pages5
JournalResearch in Veterinary Science
Volume96
Issue number3
DOIs
StatePublished - Jun 2014
Externally publishedYes

Keywords

  • Endocrinology
  • Metabolism
  • Osmolality
  • Sodium
  • Tonicity

ASJC Scopus subject areas

  • veterinary(all)

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