In vitro evaluation of the antidiabetic and antiadipogenic potential of Amaranth protein hydrolysates

Aída Jimena Velarde-Salcedo, Elvira González De Mejía, Ana Paulina Barba De La Rosa

Research output: Chapter in Book/Report/Conference proceedingChapter

Abstract

Obesity, which is a major recognized risk factor for type-2 diabetes, is rapidly increasing in prevalence resulting in a "diabesity" epidemic. Diabesity represents one of the major public health problems in the 21st century. Some of the strategies that have shown to be effective in reducing type-2 diabetes incidence are exercise and a healthy diet. New drugs that have as a target the inhibition of the enzyme dipeptidyl dipeptidase IV (DPPIV) have been released. However some of these drugs have secondary effects; for that reason, the food industry is exploring the aspects related to the components present in food that promote a healthy life, such as the bioactive peptides encrypted in the proteins of several foods. Amaranth is a plant native from North, Central and South America which contains antihypertensive, antioxidant and cancer preventive peptides. Also there is evidence that amaranth has some hypoglycemic action; however, the antidiabetic potential and the effect upon body weight of the seed proteins have not been well characterized. The aim of this study was to identify the ability of amaranth peptides to inhibit the DPPIV activity and the effect of these peptides upon fat accumulation in mouse adipocyte cultures.

Original languageEnglish (US)
Title of host publicationHispanic Foods
Subtitle of host publicationChemistry and Bioactive Compounds
PublisherAmerican Chemical Society
Pages189-198
Number of pages10
ISBN (Print)9780841227460
DOIs
StatePublished - Nov 15 2012

Publication series

NameACS Symposium Series
Volume1109
ISSN (Print)0097-6156
ISSN (Electronic)1947-5918

Fingerprint

Protein Hydrolysates
Hypoglycemic Agents
Peptides
Medical problems
Proteins
Enzyme inhibition
Public health
Nutrition
Oils and fats
Antioxidants
Pharmaceutical Preparations
Antihypertensive Agents
Seed
Enzymes
Fats
Industry
dipeptidase

ASJC Scopus subject areas

  • Chemistry(all)
  • Chemical Engineering(all)

Cite this

Velarde-Salcedo, A. J., De Mejía, E. G., & Barba De La Rosa, A. P. (2012). In vitro evaluation of the antidiabetic and antiadipogenic potential of Amaranth protein hydrolysates. In Hispanic Foods: Chemistry and Bioactive Compounds (pp. 189-198). (ACS Symposium Series; Vol. 1109). American Chemical Society. https://doi.org/10.1021/bk-2012-1109.ch012

In vitro evaluation of the antidiabetic and antiadipogenic potential of Amaranth protein hydrolysates. / Velarde-Salcedo, Aída Jimena; De Mejía, Elvira González; Barba De La Rosa, Ana Paulina.

Hispanic Foods: Chemistry and Bioactive Compounds. American Chemical Society, 2012. p. 189-198 (ACS Symposium Series; Vol. 1109).

Research output: Chapter in Book/Report/Conference proceedingChapter

Velarde-Salcedo, AJ, De Mejía, EG & Barba De La Rosa, AP 2012, In vitro evaluation of the antidiabetic and antiadipogenic potential of Amaranth protein hydrolysates. in Hispanic Foods: Chemistry and Bioactive Compounds. ACS Symposium Series, vol. 1109, American Chemical Society, pp. 189-198. https://doi.org/10.1021/bk-2012-1109.ch012
Velarde-Salcedo AJ, De Mejía EG, Barba De La Rosa AP. In vitro evaluation of the antidiabetic and antiadipogenic potential of Amaranth protein hydrolysates. In Hispanic Foods: Chemistry and Bioactive Compounds. American Chemical Society. 2012. p. 189-198. (ACS Symposium Series). https://doi.org/10.1021/bk-2012-1109.ch012
Velarde-Salcedo, Aída Jimena ; De Mejía, Elvira González ; Barba De La Rosa, Ana Paulina. / In vitro evaluation of the antidiabetic and antiadipogenic potential of Amaranth protein hydrolysates. Hispanic Foods: Chemistry and Bioactive Compounds. American Chemical Society, 2012. pp. 189-198 (ACS Symposium Series).
@inbook{0492bf77062744a8bc66913887ee22c2,
title = "In vitro evaluation of the antidiabetic and antiadipogenic potential of Amaranth protein hydrolysates",
abstract = "Obesity, which is a major recognized risk factor for type-2 diabetes, is rapidly increasing in prevalence resulting in a {"}diabesity{"} epidemic. Diabesity represents one of the major public health problems in the 21st century. Some of the strategies that have shown to be effective in reducing type-2 diabetes incidence are exercise and a healthy diet. New drugs that have as a target the inhibition of the enzyme dipeptidyl dipeptidase IV (DPPIV) have been released. However some of these drugs have secondary effects; for that reason, the food industry is exploring the aspects related to the components present in food that promote a healthy life, such as the bioactive peptides encrypted in the proteins of several foods. Amaranth is a plant native from North, Central and South America which contains antihypertensive, antioxidant and cancer preventive peptides. Also there is evidence that amaranth has some hypoglycemic action; however, the antidiabetic potential and the effect upon body weight of the seed proteins have not been well characterized. The aim of this study was to identify the ability of amaranth peptides to inhibit the DPPIV activity and the effect of these peptides upon fat accumulation in mouse adipocyte cultures.",
author = "Velarde-Salcedo, {A{\'i}da Jimena} and {De Mej{\'i}a}, {Elvira Gonz{\'a}lez} and {Barba De La Rosa}, {Ana Paulina}",
year = "2012",
month = "11",
day = "15",
doi = "10.1021/bk-2012-1109.ch012",
language = "English (US)",
isbn = "9780841227460",
series = "ACS Symposium Series",
publisher = "American Chemical Society",
pages = "189--198",
booktitle = "Hispanic Foods",

}

TY - CHAP

T1 - In vitro evaluation of the antidiabetic and antiadipogenic potential of Amaranth protein hydrolysates

AU - Velarde-Salcedo, Aída Jimena

AU - De Mejía, Elvira González

AU - Barba De La Rosa, Ana Paulina

PY - 2012/11/15

Y1 - 2012/11/15

N2 - Obesity, which is a major recognized risk factor for type-2 diabetes, is rapidly increasing in prevalence resulting in a "diabesity" epidemic. Diabesity represents one of the major public health problems in the 21st century. Some of the strategies that have shown to be effective in reducing type-2 diabetes incidence are exercise and a healthy diet. New drugs that have as a target the inhibition of the enzyme dipeptidyl dipeptidase IV (DPPIV) have been released. However some of these drugs have secondary effects; for that reason, the food industry is exploring the aspects related to the components present in food that promote a healthy life, such as the bioactive peptides encrypted in the proteins of several foods. Amaranth is a plant native from North, Central and South America which contains antihypertensive, antioxidant and cancer preventive peptides. Also there is evidence that amaranth has some hypoglycemic action; however, the antidiabetic potential and the effect upon body weight of the seed proteins have not been well characterized. The aim of this study was to identify the ability of amaranth peptides to inhibit the DPPIV activity and the effect of these peptides upon fat accumulation in mouse adipocyte cultures.

AB - Obesity, which is a major recognized risk factor for type-2 diabetes, is rapidly increasing in prevalence resulting in a "diabesity" epidemic. Diabesity represents one of the major public health problems in the 21st century. Some of the strategies that have shown to be effective in reducing type-2 diabetes incidence are exercise and a healthy diet. New drugs that have as a target the inhibition of the enzyme dipeptidyl dipeptidase IV (DPPIV) have been released. However some of these drugs have secondary effects; for that reason, the food industry is exploring the aspects related to the components present in food that promote a healthy life, such as the bioactive peptides encrypted in the proteins of several foods. Amaranth is a plant native from North, Central and South America which contains antihypertensive, antioxidant and cancer preventive peptides. Also there is evidence that amaranth has some hypoglycemic action; however, the antidiabetic potential and the effect upon body weight of the seed proteins have not been well characterized. The aim of this study was to identify the ability of amaranth peptides to inhibit the DPPIV activity and the effect of these peptides upon fat accumulation in mouse adipocyte cultures.

UR - http://www.scopus.com/inward/record.url?scp=84879134334&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=84879134334&partnerID=8YFLogxK

U2 - 10.1021/bk-2012-1109.ch012

DO - 10.1021/bk-2012-1109.ch012

M3 - Chapter

AN - SCOPUS:84879134334

SN - 9780841227460

T3 - ACS Symposium Series

SP - 189

EP - 198

BT - Hispanic Foods

PB - American Chemical Society

ER -