In vitro degradation of polyanhydride/polyester core-shell double-wall microspheres

Emily J. Pollauf, Cory Berkland, Kyekyoon Kim, Daniel W. Pack

Research output: Contribution to journalArticlepeer-review

Abstract

Double-wall microspheres (DWMS), comprising distinct polymer core and shell phases, are useful and interesting for controlled-release drug delivery. In particular, the presence of a surface-eroding polymer core may be expected to limit water penetration and, therefore, delay degradation of the core phase and drug release. In this study, solid microspheres and DWMS were fabricated using a surface-eroding polymer (poly[1,6-bis(p-carboxyphenoxy)hexane]; PCPH) and a bulk-eroding polymer (poly(d,l-lactide-co-glycolide); PLG). Erosion of the particles was observed by optical and electron microscopy, while polymer degradation was followed by gel permeation chromatography, during incubation in buffer at 37°C. Degradation and erosion were very different depending on which polymer formed the particle shell. Nevertheless, the relatively thin (∼5 μm) PCPH shells could not prevent water penetration, and the PLG cores completely eroded by 6 weeks of incubation.

Original languageEnglish (US)
Pages (from-to)294-303
Number of pages10
JournalInternational Journal of Pharmaceutics
Volume301
Issue number1-2
DOIs
StatePublished - Sep 14 2005

Keywords

  • Degradation
  • Double-wall microsphere
  • Microsphere
  • Poly(d,l-lactide-co-glycolide)
  • Polyanhydride

ASJC Scopus subject areas

  • Pharmaceutical Science

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