TY - GEN
T1 - In vitro cancer metastasis induced by mechanical force
AU - Tang, Xin
AU - Saif, Taher
PY - 2013
Y1 - 2013
N2 - Based on the American Cancer Society's report at 2004, after 50-year's efforts in bio-chemical medicine development, the U.S.A. cancer mortality is 193.9 per 100,000 persons, which is not significantly reduced from that at 1950, 185.8 per 100,000 persons. One critical reason for the clinical inefficacy is that it is not identified what signals trigger the onset of metastasis. 90% of cancer deaths are caused by metastases (1-6). During metastasis, malignant cancer cells detach from the parent cancer tumor to invade new organs (5-7). Although the primary tumor can be readily removed by surgery if detected in time, metastasis cannot be cured effectively due to the presence of numerous secondary tumors. Here we present, for the first time, that cancer cells can exhibit metastasis like phenotype (MLP) in vitro when they are experiencing appropriate mechanical stimuli.
AB - Based on the American Cancer Society's report at 2004, after 50-year's efforts in bio-chemical medicine development, the U.S.A. cancer mortality is 193.9 per 100,000 persons, which is not significantly reduced from that at 1950, 185.8 per 100,000 persons. One critical reason for the clinical inefficacy is that it is not identified what signals trigger the onset of metastasis. 90% of cancer deaths are caused by metastases (1-6). During metastasis, malignant cancer cells detach from the parent cancer tumor to invade new organs (5-7). Although the primary tumor can be readily removed by surgery if detected in time, metastasis cannot be cured effectively due to the presence of numerous secondary tumors. Here we present, for the first time, that cancer cells can exhibit metastasis like phenotype (MLP) in vitro when they are experiencing appropriate mechanical stimuli.
UR - http://www.scopus.com/inward/record.url?scp=84890060155&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=84890060155&partnerID=8YFLogxK
U2 - 10.1115/NEMB2013-93130
DO - 10.1115/NEMB2013-93130
M3 - Conference contribution
AN - SCOPUS:84890060155
SN - 9780791845332
T3 - ASME 2013 2nd Global Congress on NanoEngineering for Medicine and Biology, NEMB 2013
BT - ASME 2013 2nd Global Congress on NanoEngineering for Medicine and Biology, NEMB 2013
T2 - ASME 2013 2nd Global Congress on NanoEngineering for Medicine and Biology, NEMB 2013
Y2 - 4 February 2013 through 6 February 2013
ER -