In vitro cancer metastasis induced by mechanical force

Xin Tang, Taher Saif

Research output: Chapter in Book/Report/Conference proceedingConference contribution

Abstract

Based on the American Cancer Society's report at 2004, after 50-year's efforts in bio-chemical medicine development, the U.S.A. cancer mortality is 193.9 per 100,000 persons, which is not significantly reduced from that at 1950, 185.8 per 100,000 persons. One critical reason for the clinical inefficacy is that it is not identified what signals trigger the onset of metastasis. 90% of cancer deaths are caused by metastases (1-6). During metastasis, malignant cancer cells detach from the parent cancer tumor to invade new organs (5-7). Although the primary tumor can be readily removed by surgery if detected in time, metastasis cannot be cured effectively due to the presence of numerous secondary tumors. Here we present, for the first time, that cancer cells can exhibit metastasis like phenotype (MLP) in vitro when they are experiencing appropriate mechanical stimuli.

Original languageEnglish (US)
Title of host publicationASME 2013 2nd Global Congress on NanoEngineering for Medicine and Biology, NEMB 2013
DOIs
StatePublished - Dec 16 2013
EventASME 2013 2nd Global Congress on NanoEngineering for Medicine and Biology, NEMB 2013 - Boston, MA, United States
Duration: Feb 4 2013Feb 6 2013

Publication series

NameASME 2013 2nd Global Congress on NanoEngineering for Medicine and Biology, NEMB 2013

Other

OtherASME 2013 2nd Global Congress on NanoEngineering for Medicine and Biology, NEMB 2013
CountryUnited States
CityBoston, MA
Period2/4/132/6/13

ASJC Scopus subject areas

  • Biotechnology

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  • Cite this

    Tang, X., & Saif, T. (2013). In vitro cancer metastasis induced by mechanical force. In ASME 2013 2nd Global Congress on NanoEngineering for Medicine and Biology, NEMB 2013 [NEMB2013-93130] (ASME 2013 2nd Global Congress on NanoEngineering for Medicine and Biology, NEMB 2013). https://doi.org/10.1115/NEMB2013-93130