In-situ adhesion studies of a single living bovine endothelial cell using MEMS sensor

Chad Sager, Philip LeDuc, M Taher A Saif

Research output: Chapter in Book/Report/Conference proceedingConference contribution

Abstract

Although previous studies of the adhesion properties of single living cells have been conducted a full understanding has still not been attained. In this article a MEMS sensor has been employed to study, quantitatively and qualitatively, the adhesion properties of a single living bovine endothelial cell. The strength of a single focal adhesion site to an extracellular matrix coated substrate is found to be 37 nN. Focal adhesion sites have been observed, insitu, to be spaced on the order of 1 μm intervals. A model is also proposed to describe the mechanism of detachment of a single living cell from a substrate.

Original languageEnglish (US)
Title of host publication1st Annual International IEEE-EMBS Special Topic Conference on Microtechnologies in Medicine and Biology - Proceedings
EditorsAndre Dittmar, David Beebe
PublisherInstitute of Electrical and Electronics Engineers Inc.
Pages76-79
Number of pages4
ISBN (Electronic)0780366034, 9780780366039
DOIs
StatePublished - Jan 1 2000
Event1st Annual International IEEE-EMBS Special Topic Conference on Microtechnologies in Medicine and Biology, MMB 2000 - Lyon, France
Duration: Oct 12 2000Oct 14 2000

Publication series

Name1st Annual International IEEE-EMBS Special Topic Conference on Microtechnologies in Medicine and Biology - Proceedings

Other

Other1st Annual International IEEE-EMBS Special Topic Conference on Microtechnologies in Medicine and Biology, MMB 2000
CountryFrance
CityLyon
Period10/12/0010/14/00

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ASJC Scopus subject areas

  • Engineering(all)

Cite this

Sager, C., LeDuc, P., & Saif, M. T. A. (2000). In-situ adhesion studies of a single living bovine endothelial cell using MEMS sensor. In A. Dittmar, & D. Beebe (Eds.), 1st Annual International IEEE-EMBS Special Topic Conference on Microtechnologies in Medicine and Biology - Proceedings (pp. 76-79). [893745] (1st Annual International IEEE-EMBS Special Topic Conference on Microtechnologies in Medicine and Biology - Proceedings). Institute of Electrical and Electronics Engineers Inc.. https://doi.org/10.1109/MMB.2000.893745