In-line X-ray phase-contrast lung imaging in situ with a benchtop system

A. B. Garson, E. W. Izaguirre, S. G. Price, H. Guan, S. K. Vasireddi, M. A. Anastasio

Research output: Chapter in Book/Report/Conference proceedingConference contribution


X-ray phase-contrast (XPC) imaging methods are well-suited for lung imaging applications due To The weakly absorbing nature of lung Tissue and The strong refractive effects associated with Tissue-Air interfaces. Until recently, XPC lung imaging had only been accomplished at synchrotron facilities. In This work, we investigate The manifestation of speckle in propagation-based XPC images of mouse lungs acquired in situ by use of a benchtop imager. The key contributions of The work are: a) The demonstration That lung speckle can be observed by use of a benchtop XPC imaging system employing a polychromatic Tube-source; and b) a systematic experimental investigation of how The Texture of The speckle pattern depends on The parameters of The imaging system. Our analyses consists of image Texture characterization based on The statistical properties of pixel intensity distributions. Results show how image Texture measures of lung regions are strongly dependent on imaging system parameters associated with XPC sensitivity.

Original languageEnglish (US)
Title of host publicationMedical Imaging 2014
Subtitle of host publicationPhysics of Medical Imaging
ISBN (Print)9780819498267
StatePublished - Jan 1 2014
Externally publishedYes
EventMedical Imaging 2014: Physics of Medical Imaging - San Diego, CA, United States
Duration: Feb 17 2014Feb 20 2014

Publication series

NameProgress in Biomedical Optics and Imaging - Proceedings of SPIE
ISSN (Print)1605-7422


OtherMedical Imaging 2014: Physics of Medical Imaging
CountryUnited States
CitySan Diego, CA


  • lung imaging
  • lung speckle
  • X-ray phase-contrast imaging

ASJC Scopus subject areas

  • Atomic and Molecular Physics, and Optics
  • Electronic, Optical and Magnetic Materials
  • Biomaterials
  • Radiology Nuclear Medicine and imaging

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