Improving spatiotemporal resolution of USPIO-enhanced dynamic imaging of rat kidneys

Ying Sun, Dewen Yang, Qing Ye, Mangay Williams, José M.F. Moura, Fernando Boada, Zhi Pei Liang, Chien Ho

Research output: Contribution to journalArticlepeer-review


This paper addresses the problem of enhancing spatiotemporal resolution of ultra-small superparamagnetic iron oxide (USPIO)-enhanced dynamic MRI of rat kidneys. To alleviate the limited resolution problem of conventional full-scan Fourier imaging methods, we use a generalized series-based imaging scheme to reduce coverage of k-space. Experimental results demonstrate that the generalized series imaging method with basis functions constructed using two references (pre- and post-contrast) can reduce the number of phase encodings measured during the dynamic contrast wash-in process by a factor of 4 with a negligible or minimal loss of image quality. The method is expected to make 3D studies possible using USPIO-enhanced dynamic imaging of rat kidneys, and prove valuable for early detection of renal rejection after kidney transplantation.

Original languageEnglish (US)
Pages (from-to)593-598
Number of pages6
JournalMagnetic Resonance Imaging
Issue number6
StatePublished - Jul 2003

ASJC Scopus subject areas

  • Biophysics
  • Biomedical Engineering
  • Radiology Nuclear Medicine and imaging


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