Improved model-based magnetic resonance spectroscopic imaging

Mathews Jacob, Xiaoping Zhu, Andreas Ebel, Norbert Schuff, Zhi Pei Liang

Research output: Contribution to journalArticle


Model-based techniques have the potential to reduce the artifacts and improve resolution in magnetic resonance spectroscopic imaging, without sacrificing the signal-to-noise ratio. However, the current approaches have a few drawbacks that limit their performance in practical applications. Specifically, the classical schemes use less flexible image models that lead to model misfit, thus resulting in artifacts. Moreover, the performance of the current approaches is negatively affected by the magnetic field inhomogeneity and spatial mismatch between the anatomical references and spectroscopic imaging data. In this paper, we propose efficient solutions to overcome these problems. We introduce a more flexible image model that represents the signal as a linear combination of compartmental and local basis functions. The former set represents the signal variations within the compartments, while the latter captures the local perturbations resulting from lesions or segmentation errors. Since the combined set is redundant, we obtain the reconstructions using sparsity penalized optimization. To compensate for the artifacts resulting from field inhomogeneity, we estimate the field map using alternate scans and use it in the reconstruction. We model the spatial mismatch as an affine transformation, whose parameters are estimated from the spectroscopy data.

Original languageEnglish (US)
Pages (from-to)1305-1318
Number of pages14
JournalIEEE transactions on medical imaging
Issue number10
StatePublished - Oct 1 2007


  • Constrained reconstruction
  • Inhomogeneity compensation
  • Prior information
  • Spectroscopic imaging

ASJC Scopus subject areas

  • Biomedical Engineering
  • Radiology Nuclear Medicine and imaging
  • Radiological and Ultrasound Technology
  • Electrical and Electronic Engineering
  • Computer Science Applications
  • Computational Theory and Mathematics

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