Improved chemical syntheses of 5,6-dihydro-5-fluorouracil

Andrew L. LaFrate, John A. Katzenellenbogen

Research output: Contribution to journalArticlepeer-review


(Chemical Equation Presented) 5,6-Dihydro-5-fluorouracil (5-DHFU) is a metabolite of the chemotherapy drug 5-fluorouracil (5-FU) of importance for biological studies. 5-DHFU has been prepared by enzymatic reduction of 5-FU and in very low yield by hydrogenation of 5-FU; however, a practical chemical synthesis is not available. Facile racemic syntheses of 5-DHFU from 5-FU or uracil, using p-methoxybenzyl protecting groups followed by L-Selectride reduction, are reported.

Original languageEnglish (US)
Pages (from-to)8573-8576
Number of pages4
JournalJournal of Organic Chemistry
Issue number22
StatePublished - Oct 26 2007

ASJC Scopus subject areas

  • Organic Chemistry


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