Abstract
(Chemical Equation Presented) 5,6-Dihydro-5-fluorouracil (5-DHFU) is a metabolite of the chemotherapy drug 5-fluorouracil (5-FU) of importance for biological studies. 5-DHFU has been prepared by enzymatic reduction of 5-FU and in very low yield by hydrogenation of 5-FU; however, a practical chemical synthesis is not available. Facile racemic syntheses of 5-DHFU from 5-FU or uracil, using p-methoxybenzyl protecting groups followed by L-Selectride reduction, are reported.
| Original language | English (US) |
|---|---|
| Pages (from-to) | 8573-8576 |
| Number of pages | 4 |
| Journal | Journal of Organic Chemistry |
| Volume | 72 |
| Issue number | 22 |
| DOIs | |
| State | Published - Oct 26 2007 |
ASJC Scopus subject areas
- Organic Chemistry