Importance of Asparagine 202 in Manipulating Active Site Structure and Substrate Preference for Human CYP17A1

Keyphrases

• Human Cytochrome P450 100%
• Active Site Structure 100%
• Asparagine 100%
• Lyase 100%
• Pregnenolone 100%
• Substrate Preference 100%
• Structure Preference 100%
• Cytochrome P450 17A1 100%
• 17-OH Progesterone 75%
• Peroxo 50%
• Active Sites 25%
• Structural Change 25%
• Reaction Intermediates 25%
• Estrogen 25%
• Androgens 25%
• Resonance Raman 25%
• Progesterone 25%
• Raman Technique 25%
• Compound I 25%
• Kcat 25%
• Hydroxylated 25%
• Substrate Orientation 25%
• Hydroperoxo 25%
• Carbon-carbon Bond 25%
• Monooxygenase 25%
• Asparagine Residue 25%
• Km Value 25%
• Hydrogen Abstraction 25%
• Androstenedione 25%
• H-bonding Interaction 25%
• Dehydroepiandrosterone 25%
• Solvent Isotope Effect 25%
• Hemiketal 25%
• Steroid Hormone Biosynthesis 25%
• Substrate Control 25%
• Hydrogen Radical 25%
• Active Intermediate 25%
• Peroxo Intermediates 25%
• Cryoradiolysis 25%
• Rebound Mechanism 25%
• Radical Recombination 25%
• Protonation Degree 25%
• Peroxo Species 25%
• Oxygen Rebound 25%

Biochemistry, Genetics and Molecular Biology

• Active Site 100%
• Lyase 100%
• Asparagine 100%
• Cytochrome P450 100%
• Progesterone 100%
• Pregnenolone 100%
• Precursor 25%
• Protonation 25%
• Catalytic Efficiency 25%
• Unspecific Monooxygenase 25%
• Rebound 25%
• Steroid Biosynthesis 25%
• Dehydroepiandrosterone 25%
• Serine 25%

Chemistry

• Asparagine 100%
• Progesterone 100%
• Cytochrome P450 100%
• Pregnenolone 100%
• Lyase Reaction 50%
• Chemistry 25%
• Hydrogen 25%
• Reaction Intermediate 25%
• Monooxygenase 25%
• Asparagine Residue 25%
• Kcat/Km 25%
• Hemiketal 25%
• Androstenedione 25%
• protonation 25%
• Isotope Effect 25%
• Dehydroepiandrosterone 25%
• Serine 25%
• Androgen 25%
• Steroid Hormone 25%