@article{87e72564e1ab443fbdef56a8bc74a08a,
title = "Impaired Neurovascular Coupling and Increased Functional Connectivity in the Frontal Cortex Predict Age-Related Cognitive Dysfunction",
abstract = "Impaired cerebrovascular function contributes to the genesis of age-related cognitive decline. In this study, the hypothesis is tested that impairments in neurovascular coupling (NVC) responses and brain network function predict cognitive dysfunction in older adults. Cerebromicrovascular and working memory function of healthy young (n = 21, 33.2±7.0 years) and aged (n = 30, 75.9±6.9 years) participants are assessed. To determine NVC responses and functional connectivity (FC) during a working memory (n-back) paradigm, oxy- and deoxyhemoglobin concentration changes from the frontal cortex using functional near-infrared spectroscopy are recorded. NVC responses are significantly impaired during the 2-back task in aged participants, while the frontal networks are characterized by higher local and global connection strength, and dynamic FC (p < 0.05). Both impaired NVC and increased FC correlate with age-related decline in accuracy during the 2-back task. These findings suggest that task-related brain states in older adults require stronger functional connections to compensate for the attenuated NVC responses associated with working memory load.",
keywords = "aging, cognitive decline, functional connectivity, functional near-infrared spectroscopy, neurovascular coupling",
author = "Peter Mukli and Pinto, {Camila B.} and Owens, {Cameron D.} and Tamas Csipo and Agnes Lipecz and Zsofia Szarvas and Anna Peterfi and Langley, {Ana Clara da Costa Pinaffi} and Jordan Hoffmeister and Racz, {Frigyes Samuel} and Perry, {Jonathan W.} and Stefano Tarantini and {\'A}d{\'a}m Ny{\'u}l-T{\'o}th and Sorond, {Farzaneh A.} and Yuan Yang and James, {Judith A.} and Kirkpatrick, {Angelia C.} and Prodan, {Calin I.} and Peter Toth and Juliette Galindo and Gardner, {Andrew W.} and Sonntag, {William E.} and Anna Csiszar and Zoltan Ungvari and Andriy Yabluchanskiy",
note = "P.M., C.B.P., C.O., T.C., and A.L. contributed equally to this work. Research reported in this publication was supported by the American Heart Association (AHA966924, AHA834339, AHA941290, AHA932980, 23DIVSUP1070991), the National Institute on Aging of National Institutes of Health (R01AG075834, RF1AG072295, R01AG055395, R01AG068295, K01AG073614, R03AG070479, R01HD109157, RF1NS085002), the National Institute of Neurological Disorders and Stroke (R01NS100782), the US Department of Veterans Affairs (Merit award number CX002578 and CX000340), and the National Cancer Institute (R01CA255840) of the National Institutes of Health. This research was also supported by the Oklahoma Shared Clinical and Translational Resources (U54GM104938) with an Institutional Development Award (IDeA) from NIGMS, the NIA‐supported Geroscience Training Program in Oklahoma (T32AG052363), the Oklahoma Nathan Shock Center (P30AG050911), the Cellular and Molecular GeroScience CoBRE (P20GM125528, project 5337), the NCI Cancer Center Support Grant (P30CA225520) and the Oklahoma Tobacco Settlement Endowment Trust, and the National Science Foundation (NSF2236459). The content is solely the responsibility of the authors and does not necessarily represent the official views of the National Institutes of Health. This work was also partly supported by the National Research, Development and Innovation Fund from the Ministry of Innovation and Technology of Hungary, through the TKP2021‐NKTA funding scheme (project no. TKP2021‐NKTA‐47) and through the National Cardiovascular Laboratory Program (RRF‐2.3.1‐21‐2022‐00003).",
year = "2024",
month = mar,
day = "13",
doi = "10.1002/advs.202303516",
language = "English (US)",
volume = "11",
journal = "Advanced Science",
issn = "2198-3844",
publisher = "Wiley-VCH",
number = "10",
}