Impact of CRISPR immunity on the emergence and virulence of bacterial pathogens

Asma Hatoum-Aslan, Luciano A. Marraffini

Research output: Contribution to journalReview articlepeer-review

Abstract

CRISPR-Cas systems protect prokaryotes from viruses and plasmids and function primarily as an adaptive immune system in these organisms. Recent discoveries, however, revealed unexpected roles for CRISPR loci as barriers to horizontal gene transfer and as modulators of gene expression. We review how both of these functions of CRISPR-Cas systems can affect the emergence and virulence of human bacterial pathogens.

Original languageEnglish (US)
Pages (from-to)82-90
Number of pages9
JournalCurrent Opinion in Microbiology
Volume17
Issue number1
DOIs
StatePublished - Feb 2014
Externally publishedYes

ASJC Scopus subject areas

  • Microbiology
  • Microbiology (medical)
  • Infectious Diseases

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