Immunomodulatory activity of Lactobacillus strains isolated from fermented vegetables and infant stool

Tae Joon Won, Bongjoon Kim, Eun Seul Oh, Joon Seok Bang, Yoon Jeong Lee, Jong Sun Yoo, Hyunmin Yu, Joowon Yoon, Kyeong Eun Hyung, So Young Park, Kwang Woo Hwang

Research output: Contribution to journalArticlepeer-review


Four Lactobacillus strains - Lactobacillus plantarum CJLP133, L. plantarum CJLP243, L. plantarum CJNR26, and Lactobacillus gasseri CJMF3 - were isolated from Korean fermented food or healthy infant feces, and their capacity to modulate cellular and humoral immune responses was studied. Feeding of the tested lactobacilli for 8 weeks did not alter the weight of and cell numbers in the spleen of mice. However, CJLP133 and CJLP243 strains increased the T lymphocyte population in the spleen of mice, while CJNR26 and CJMF3 increased the B lymphocyte population. In splenocytes treated with concanavalin A, ingestion of CJLP133 and CJLP243 promoted T lymphocyte proliferation and secretion of T cell cytokines, whereas feeding of the CJNR26 and CJMF3 strains enhanced B lymphocyte proliferation in splenocytes treated with lipopolysaccharide and plaque formation. These results suggest that CJLP133 and CJLP243 have immunostimulating activity through the enhancement of T cell activation, while CJNR26 and CJMF3 exhibit immunopotentiation through the increment of B cell activation.

Original languageEnglish (US)
Pages (from-to)429-434
Number of pages6
JournalCanadian Journal of Physiology and Pharmacology
Issue number6
StatePublished - Jun 2011
Externally publishedYes


  • B lymphocyte
  • Fermented food
  • Immunomodulation
  • Lactobacillus
  • T lymphocyte

ASJC Scopus subject areas

  • Physiology
  • Pharmacology
  • Physiology (medical)


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