Immunology 102 at poxvirus U: Avoiding apoptosis

Joanna L. Shisler, Bernard Moss

Research output: Contribution to journalArticlepeer-review

Abstract

Poxviruses are large complex viruses that replicate in the cytoplasm of cells without integrating their DNA into the host genome or undergoing a latent intracellular stage. In addition to viral enzymes for DNA and RNA synthesis, poxviruses encode many proteins that modulate host responses. These include inhibitors of apoptosis induced by ligand binding to cell surface receptors, peroxides, ultraviolet light, DNA damaging agents and other cell signaling pathways.

Original languageEnglish (US)
Pages (from-to)67-72
Number of pages6
JournalSeminars in Immunology
Volume13
Issue number1
DOIs
StatePublished - 2001
Externally publishedYes

Keywords

  • Apoptosis
  • Caspase
  • Cell death
  • Poxvirus

ASJC Scopus subject areas

  • Immunology and Allergy
  • Immunology

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