Immunohistochemical profile of human pancreatic pacinian corpuscles

Olivia García-Suárez, Marta G. Calavia, Francisco J. Pérez-Moltó, Covadonga Alvarez-Abad, Pablo Pérez-Piñera, Juan M. Cobo, José A. Vega

Research output: Contribution to journalArticlepeer-review

Abstract

Objectives: To analyze the immunohistochemical profile of the human pancreatic pacinian corpuscles in comparison with that of the cutaneous pacinian corpuscles. In addition, we studied a Pacinilike corpuscle found in the adventitia of a pancreatic artery. Methods: We used immunohistochemistry to detect specific antigens for corpuscular constituents, specific antibodies for the identification of Aδ- and C-sensory fibers and for the detection of several growth factor receptors, and some members of the degenerin/epithelial Na channel superfamily of proteins. Results: Approximately 62% of pancreatic pacinian corpuscles have 2 to 10 axonic profiles each enclosed by its own inner core: 1 or 2 of these axonic profiles displayed RT-97 immunoreactivity (specific marker of mechanical axons). The cutaneous pacinian corpuscles showed not more than 2 axonic profiles with identical immunohistochemical characteristics. The expression of glial fibrillary acidic protein, epithelial membrane antigen, and tyrosine receptor kinase B was different between pancreatic and cutaneous pacinian corpuscles; the pattern of distribution of degenerin/epithelial Na channel proteins was identical in both cases. The arterial Pacinilike corpuscles displayed a specific immunohistochemical profile. Conclusions: Pancreatic pacinian corpuscles slightly differ from the cutaneous ones, and these differences could be related to topography, growth factor requirements, or function of pacinian corpuscles in the pancreas.

Original languageEnglish (US)
Pages (from-to)403-410
Number of pages8
JournalPancreas
Volume39
Issue number3
DOIs
StatePublished - Apr 2010
Externally publishedYes

Keywords

  • Blood vessels
  • Human pacinian corpuscles
  • Immunohistochemistry
  • Pancreas
  • Skin

ASJC Scopus subject areas

  • Hepatology
  • Internal Medicine
  • Endocrinology
  • Endocrinology, Diabetes and Metabolism

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