Immunohistochemical characterization of a hepatic neuroendocrine carcinoma in a cat

Patricia Ferreira-Neves, Stéphane Lezmi, Typhaine Lejeune, Farasao Rakotovao, Claire Dally, Jean Jacques Fontaine, Florence Bernex, Nathalie Cordonnier

Research output: Contribution to journalArticlepeer-review


A hepatic mass was identified in a 5-year-old, female mixed-breed cat that died spontaneously after a clinical history of progressive emaciation, ptyalism, and persistent coryza. At necropsy, a 7-cm-diameter, yellow-brown, firm, multilobulated tumor was identified in the liver. Microscopically, the mass consisted of neoplastic cells arranged in small, closely packed nests within a thin fibrovascular stroma. These cells were of medium sized and polygonal, with fine argyrophilic cytoplasmic granules. Nuclei were predominantly round with finely stippled chromatin and indistinct nucleoli. Mitotic figures were numerous. Immunohistochemically, most of the neoplastic cells were immunoreactive for chromogranin A, neuronspecific enolase (NSE), and cytokeratin AE1/AE3 and weakly labeled for synaptophysin. The tumor was negative for glial fibrillary acidic protein (GFAP), vimentin, and cytokeratins 5, 6, 8, and 17. Vascular emboli and intrahepatic micrometastasis were also identified with chromogranin A. All these features were consistent with a hepatic neuroendocrine carcinoma and emphasized the importance of using a panel of antibodies to diagnose such rare tumors.

Original languageEnglish (US)
Pages (from-to)110-114
Number of pages5
JournalJournal of Veterinary Diagnostic Investigation
Issue number1
StatePublished - Jan 1 2008
Externally publishedYes


  • Cats
  • Chromogranin A
  • Hepatic tumor
  • Liver
  • Neuroendocrine carcinoma

ASJC Scopus subject areas

  • General Veterinary


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