Immune evasion strategies of molluscum contagiosum virus

Research output: Chapter in Book/Report/Conference proceedingChapter

Abstract

Molluscum contagiosum virus (MCV) is the causative agent of molluscum contagiosum (MC), the third most common viral skin infection in children, and one of the five most prevalent skin diseases worldwide. No FDA-approved treatments, vaccines, or commercially available rapid diagnostics for MCV are available. This review discusses several aspects of this medically important virus including: physical properties of MCV, MCV pathogenesis, MCV replication, and immune responses to MCV infection. Sequencing of the MCV genome revealed novel immune evasion molecules which are highlighted here. Special attention is given to the MCV MC159 and MC160 proteins. These proteins are FLIPs with homologs in gamma herpesviruses and in the cell. They are of great interest because each protein regulates apoptosis, NF-κB, and IRF3. However, the mechanism that each protein uses to impart its effects is different. It is important to elucidate how MCV inhibits immune responses; this knowledge contributes to our understanding of viral pathogenesis and also provides new insights into how the immune system neutralizes virus infections.

Original languageEnglish (US)
Title of host publicationAdvances in Virus Research
PublisherAcademic Press Inc.
Pages201-252
Number of pages52
DOIs
StatePublished - Jan 1 2015

Publication series

NameAdvances in Virus Research
Volume92
ISSN (Print)0065-3527
ISSN (Electronic)1557-8399

Keywords

  • Apoptosis
  • IRF3
  • Immune evasion
  • Molluscum contagiosum virus
  • NF-KB
  • Poxvirus

ASJC Scopus subject areas

  • Virology
  • Infectious Diseases

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  • Cite this

    Shisler, J. L. (2015). Immune evasion strategies of molluscum contagiosum virus. In Advances in Virus Research (pp. 201-252). (Advances in Virus Research; Vol. 92). Academic Press Inc.. https://doi.org/10.1016/bs.aivir.2014.11.004