Abstract

The use of matrix-assisted laser desorption/ionization (MALDI) mass spectrometry (MS) in imaging neuropeptide distribution in exocrine tissues, ganglion sections, and from neuron subsections was discussed. The technology was used to characterize the distribution of known and novel peptides involved with the feeding and reproductive behaviors of Aplysia. MS imaging analysis provided more accurate spatial information on the chemical messengers contained in both intracellular and extracellular regions of cultured cells and networks. The method was found to be useful to probe neuropeptide processing, release, and transport to increase understanding of the diversity and interaction of signal mediators in simple neuronal networks.

Original languageEnglish (US)
Title of host publicationProceedings - 50th ASMS Conference on Mass Spectrometry and Allied Topics
Pages777-778
Number of pages2
StatePublished - 2002
EventProceedings - 50th ASMS Conference on Mass Spectrometry and Allied Topics - Orlando, FL, United States
Duration: Jun 2 2002Jun 6 2002

Other

OtherProceedings - 50th ASMS Conference on Mass Spectrometry and Allied Topics
CountryUnited States
CityOrlando, FL
Period6/2/026/6/02

ASJC Scopus subject areas

  • Spectroscopy

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  • Cite this

    Kruse, R. A., Romanova, E. V., Rubakhin, S., Page, J., & Sweedler, J. V. (2002). Imaging neuropeptide distribution in Aplysia central nervous system. In Proceedings - 50th ASMS Conference on Mass Spectrometry and Allied Topics (pp. 777-778)