Abstract

The use of matrix-assisted laser desorption/ionization (MALDI) mass spectrometry (MS) in imaging neuropeptide distribution in exocrine tissues, ganglion sections, and from neuron subsections was discussed. The technology was used to characterize the distribution of known and novel peptides involved with the feeding and reproductive behaviors of Aplysia. MS imaging analysis provided more accurate spatial information on the chemical messengers contained in both intracellular and extracellular regions of cultured cells and networks. The method was found to be useful to probe neuropeptide processing, release, and transport to increase understanding of the diversity and interaction of signal mediators in simple neuronal networks.

Original languageEnglish (US)
Title of host publicationProceedings - 50th ASMS Conference on Mass Spectrometry and Allied Topics
Pages777-778
Number of pages2
StatePublished - 2002
EventProceedings - 50th ASMS Conference on Mass Spectrometry and Allied Topics - Orlando, FL, United States
Duration: Jun 2 2002Jun 6 2002

Other

OtherProceedings - 50th ASMS Conference on Mass Spectrometry and Allied Topics
CountryUnited States
CityOrlando, FL
Period6/2/026/6/02

Fingerprint

Neurology
Neuropeptides
Mass spectrometry
Imaging techniques
Neurons
Ionization
Desorption
Cells
Tissue
Peptides
Lasers
Processing

ASJC Scopus subject areas

  • Spectroscopy

Cite this

Kruse, R. A., Romanova, E. V., Rubakhin, S., Page, J., & Sweedler, J. V. (2002). Imaging neuropeptide distribution in Aplysia central nervous system. In Proceedings - 50th ASMS Conference on Mass Spectrometry and Allied Topics (pp. 777-778)

Imaging neuropeptide distribution in Aplysia central nervous system. / Kruse, Rebecca A.; Romanova, Elena Vikentievna; Rubakhin, Stanislav; Page, Jason; Sweedler, Jonathan V.

Proceedings - 50th ASMS Conference on Mass Spectrometry and Allied Topics. 2002. p. 777-778.

Research output: Chapter in Book/Report/Conference proceedingConference contribution

Kruse, RA, Romanova, EV, Rubakhin, S, Page, J & Sweedler, JV 2002, Imaging neuropeptide distribution in Aplysia central nervous system. in Proceedings - 50th ASMS Conference on Mass Spectrometry and Allied Topics. pp. 777-778, Proceedings - 50th ASMS Conference on Mass Spectrometry and Allied Topics, Orlando, FL, United States, 6/2/02.
Kruse RA, Romanova EV, Rubakhin S, Page J, Sweedler JV. Imaging neuropeptide distribution in Aplysia central nervous system. In Proceedings - 50th ASMS Conference on Mass Spectrometry and Allied Topics. 2002. p. 777-778
Kruse, Rebecca A. ; Romanova, Elena Vikentievna ; Rubakhin, Stanislav ; Page, Jason ; Sweedler, Jonathan V. / Imaging neuropeptide distribution in Aplysia central nervous system. Proceedings - 50th ASMS Conference on Mass Spectrometry and Allied Topics. 2002. pp. 777-778
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