Abstract
We studied collagen fiber organization in tissue affected by pelvic organ prolapse (POP) and compared it to asymptomatic controls. Both the control and POP tissue biopsies were prepared and measured by a highly sensitive quantitative phase imaging (QPI) system, called spatial light interference microscopy (SLIM). Combined with automatic image processing, this modality provides quantitative, high-throughput assessment of fiber morphology. We found the fiber orientation in prolapsed specimens is less homogeneous, indicating an abnormal organization of collagen in the extracellular matrix (ECM).
Original language | English (US) |
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Article number | 72 |
Journal | Frontiers in Physics |
Volume | 7 |
Issue number | May |
DOIs | |
State | Published - 2019 |
Keywords
- Fiber extraction
- Imaging processing
- Pelvic organ prolapse
- Quantitative Phase Imaging (QPI)
- SLIM
- Tissue
ASJC Scopus subject areas
- Biophysics
- Materials Science (miscellaneous)
- Mathematical Physics
- General Physics and Astronomy
- Physical and Theoretical Chemistry