Imaging angiogenesis

Lawrence W. Dobrucki, Albert J. Sinusas

Research output: Contribution to journalReview article

Abstract

Angiogenesis represents the formation of new capillaries by cellular outgrowth from existing microvessels and plays a critical role in the response to ischemia associated with peripheral arterial disease and myocardial infarction. Imaging of angiogenesis would be valuable in risk stratification of patients with arterial occlusive disease. The progress in noninvasive imaging strategies to assess angiogenesis has been made possible with the availability of many technological advances, which include dedicated hybrid SPECT-CT and PET-CT systems and agents targeted at molecular markers of the angiogenic process, involving both receptor-probe interactions and reporter gene technology. These novel targeted approaches for imaging angiogenesis will complement standard imaging of physiological parameters and will play a crucial role for evaluation of therapeutic interventions to promote angiogenesis.

Original languageEnglish (US)
Pages (from-to)90-96
Number of pages7
JournalCurrent Opinion in Biotechnology
Volume18
Issue number1
DOIs
StatePublished - Feb 1 2007
Externally publishedYes

Fingerprint

Arterial Occlusive Diseases
Peripheral Arterial Disease
Microvessels
Reporter Genes
Ischemia
Myocardial Infarction
Technology
Imaging techniques
Therapeutics
Genes
Availability
Single Photon Emission Computed Tomography Computed Tomography
Positron Emission Tomography Computed Tomography

ASJC Scopus subject areas

  • Biotechnology
  • Bioengineering
  • Biomedical Engineering

Cite this

Imaging angiogenesis. / Dobrucki, Lawrence W.; Sinusas, Albert J.

In: Current Opinion in Biotechnology, Vol. 18, No. 1, 01.02.2007, p. 90-96.

Research output: Contribution to journalReview article

Dobrucki, Lawrence W. ; Sinusas, Albert J. / Imaging angiogenesis. In: Current Opinion in Biotechnology. 2007 ; Vol. 18, No. 1. pp. 90-96.
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