@inproceedings{e064a98ff6ab4a83984e6904fe25f465,
title = "Image reconstruction in transcranial photoacoustic computed tomography of the brain",
abstract = "Photoacoustic computed tomography (PACT) holds great promise for transcranial brain imaging. However, the strong reflection, scattering, attenuation, and mode-conversion of photoacoustic waves in the skull pose serious challenges to establishing the method. The lack of an appropriate model of solid media in conventional PACT imaging models, which are based on the canonical scalar wave equation, causes a significant model mismatch in the presence of the skull and thus results in deteriorated reconstructed images. The goal of this study was to develop an image reconstruction algorithm that accurately models the skull and thereby ameliorates the quality of reconstructed images. The propagation of photoacoustic waves through the skull was modeled by a viscoelastic stress tensor wave equation, which was subsequently discretized by use of a staggered grid fourth-order finite-difference time-domain (FDTD) method. The matched adjoint of the FDTD-based wave propagation operator was derived for implementing a backprojection operator. Systematic computer simulations were conducted to demonstrate the effectiveness of the backprojection operator for reconstructing images in a realistic three-dimensional PACT brain imaging system. The results suggest that the proposed algorithm can successfully reconstruct images from transcranially-measured pressure data and readily be translated to clinical PACT brain imaging applications.",
keywords = "Brain imaging, Image reconstruction, Photoacoustic computed tomography",
author = "Kenji Mitsuhashi and Wang, {Lihong V.} and Anastasio, {Mark A.}",
note = "Publisher Copyright: {\textcopyright} 2015 SPIE.; Photons Plus Ultrasound: Imaging and Sensing 2015 ; Conference date: 08-02-2015 Through 10-02-2015",
year = "2015",
doi = "10.1117/12.2081050",
language = "English (US)",
series = "Progress in Biomedical Optics and Imaging - Proceedings of SPIE",
publisher = "SPIE",
editor = "Oraevsky, {Alexander A.} and Wang, {Lihong V.}",
booktitle = "Photons Plus Ultrasound",
address = "United States",
}