Image reconstruction in quantitative X-ray phase-contrast imaging employing multiple measurements

Cheng Ying Chou, Yin Huang, Daxin Shi, Mark A. Anastasio

Research output: Contribution to journalArticlepeer-review


X-ray phase-contrast imaging is a technique that aims to reconstruct the projected absorption and refractive index distributions of an object. One common feature of reconstruction formulas for phase-contrast imaging is the presence of isolated Fourier domain singularities, which can greatly amplify the noise levels in the estimated Fourier domain and lead to noisy and/or distorted images in spatial domain. In this article, we develop a statistically optimal reconstruction method that employs multiple (> 2) measurement states to mitigate the noise amplification effects due to singularities in the reconstruction formula. Computer-simulation studies are carried out to quantitatively and systematically investigate the developed method, within the context of propagation-based X-ray phase-contrast imaging. The reconstructed images are shown to possess dramatically reduced noise levels and greatly enhanced imaging contrast.

Original languageEnglish (US)
Pages (from-to)10002-10025
Number of pages24
JournalOptics Express
Issue number16
StatePublished - Aug 6 2007
Externally publishedYes

ASJC Scopus subject areas

  • Atomic and Molecular Physics, and Optics


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