IL-6 induced proliferation and cytotoxic activity of CD8+T cells is elevated by SUMO2 overexpression

Yun Jung Lee, Tae Joon Won, Kyeong Eun Hyung, Ye Won Jang, Soo Jeong Kim, Do Ik Lee, So Young Park, Kwang Woo Hwang

Research output: Contribution to journalArticlepeer-review


T cells play an important role in adaptive immune responses that destroy pathogens or infected cells. Therefore, regulation of T cell activity is important in various diseases, such as autoimmune diseases, hypersensitivity, and cancer. The conjugation of small ubiquitin-related modifier (SUMO) is a post-translational protein modification that regulates activity, stability, and subcellular translocation of target proteins. In this study, CD8+T cells overexpressing SUMO2 showed greater proliferation and cytotoxic activity against tumor cells in the presence of IL-6 than wild-type CD8+T cells in vitro. These CD8+T cell functions were suppressed during treatment with MEK1 or PI3K-specific inhibitors. Therefore, our findings suggest that IL-6-derived signaling pathways, including the MEK1 and PI3K pathways, are upregulated by SUMO2 overexpression. However, transgenic expression of SUMO2 in T cells did not modulate Th1/2 balance. Collectively, our results showed that SUMO2-Tg promotes cytotoxic activity against tumor cells by increasing the proliferation and cytotoxicity of CD8+T cells.

Original languageEnglish (US)
Pages (from-to)705-712
Number of pages8
JournalArchives of Pharmacal Research
Issue number5
StatePublished - May 1 2016
Externally publishedYes


  • CD8T cells
  • Cytotoxicity
  • IL-6
  • Proliferation
  • SUMO2

ASJC Scopus subject areas

  • Molecular Medicine
  • Drug Discovery
  • Organic Chemistry


Dive into the research topics of 'IL-6 induced proliferation and cytotoxic activity of CD8+T cells is elevated by SUMO2 overexpression'. Together they form a unique fingerprint.

Cite this