TY - JOUR
T1 - Idiopathic thrombocytopenic purpura in a cat
AU - Garon, Catherine L.
AU - Scott, Michael A.
AU - Selting, Kim A.
AU - Cohn, Leah A.
PY - 1999
Y1 - 1999
N2 - An 11-year-old, castrated, male domestic shorthair cat was presented for hematuria and pollakiuria. The cat had a marked thrombocytopenia, and a bone- marrow core biopsy demonstrated megakaryocytic hyperplasia with many megakaryocyte-associated neutrophils (i.e., emperipolesis). On peripheral blood, collected at initial presentation, what appeared to be platelets were noted to be within or adherent to occasional neutrophils. The thrombocytopenia was idiopathic in that no definitive cause could be found. However, platelet concentrations appeared to increase and decrease in response to changes in prednisone and cyclosporine therapy, suggesting a possible immune-mediated pathogenesis. As tests to detect increased feline platelet-associated antibodies are unavailable, immune-mediated thrombocytopenia can only be tentatively diagnosed in cats by exclusion and response to therapy.
AB - An 11-year-old, castrated, male domestic shorthair cat was presented for hematuria and pollakiuria. The cat had a marked thrombocytopenia, and a bone- marrow core biopsy demonstrated megakaryocytic hyperplasia with many megakaryocyte-associated neutrophils (i.e., emperipolesis). On peripheral blood, collected at initial presentation, what appeared to be platelets were noted to be within or adherent to occasional neutrophils. The thrombocytopenia was idiopathic in that no definitive cause could be found. However, platelet concentrations appeared to increase and decrease in response to changes in prednisone and cyclosporine therapy, suggesting a possible immune-mediated pathogenesis. As tests to detect increased feline platelet-associated antibodies are unavailable, immune-mediated thrombocytopenia can only be tentatively diagnosed in cats by exclusion and response to therapy.
UR - http://www.scopus.com/inward/record.url?scp=0032699684&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=0032699684&partnerID=8YFLogxK
U2 - 10.5326/15473317-35-6-464
DO - 10.5326/15473317-35-6-464
M3 - Article
C2 - 10580904
AN - SCOPUS:0032699684
SN - 0587-2871
VL - 35
SP - 464
EP - 470
JO - Journal of the American Animal Hospital Association
JF - Journal of the American Animal Hospital Association
IS - 6
ER -