Identification of Core Genes Involved in the Progression of Cervical Cancer Using an Integrative mRNA Analysis

Marina Dudea-Simon, Dan Mihu, Alexandru Irimie, Roxana Cojocneanu, Schuyler S. Korban, Radu Oprean, Cornelia Braicu, Ioana Berindan-Neagoe

Research output: Contribution to journalArticlepeer-review


In spite of being a preventable disease, cervical cancer (CC) remains at high incidence, and it has a significant mortality rate. Although hijacking of the host cellular pathway is fundamental for developing a better understanding of the human papillomavirus (HPV) pathogenesis, a major obstacle is identifying the central molecular targets involved in HPV-driven CC. The aim of this study is to investigate transcriptomic patterns of HPV-infected and normal tissues to identify novel prognostic markers. Analyses of functional enrichment and interaction networks reveal that altered genes are mainly involved in cell cycle, DNA damage, and regulated cell-to-cell signaling. Analysis of The Cancer Genome Atlas (TCGA) data has suggested that patients with unfavorable prognostics are more likely to have DNA repair defects attributed, in most cases, to the presence of HPV. However, further studies are needed to fully unravel the molecular mechanisms of such genes involved in CC.

Original languageEnglish (US)
Article number7323
Pages (from-to)1-22
Number of pages22
JournalInternational journal of molecular sciences
Issue number19
StatePublished - Oct 3 2020


  • Cervical cancer
  • Integrative analysis
  • MRNA
  • TCGA data

ASJC Scopus subject areas

  • Catalysis
  • Molecular Biology
  • Spectroscopy
  • Computer Science Applications
  • Physical and Theoretical Chemistry
  • Organic Chemistry
  • Inorganic Chemistry


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