Identification from a Combinatorial Library of a Small Molecule that Selectively Induces Apoptosis in Cancer Cells

Vitaliy Nesterenko, Karson S. Putt, Paul J. Hergenrother

Research output: Contribution to journalArticlepeer-review

Abstract

The selective induction of death in cancer cells is a major challenge in modern medicine. In this communication we describe the synthesis of an 88-membered combinatorial library, and the subsequent evaluation of these compounds for their ability to selectively induce apoptosis in cancerous cells. A compound was identified from the library that induces apoptosis in U-937 and HL-60 cell lines. This compound is a remarkably selective pro-apoptotic agent for these cancer cell lines, as it does not induce significant death in noncancerous white blood cells, even at concentrations as high as 1000 μM.

Original languageEnglish (US)
Pages (from-to)14672-14673
Number of pages2
JournalJournal of the American Chemical Society
Volume125
Issue number48
DOIs
StatePublished - Dec 3 2003

ASJC Scopus subject areas

  • Catalysis
  • Chemistry(all)
  • Biochemistry
  • Colloid and Surface Chemistry

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