Abstract
The rapid infusion of 0.9% NaCl solution produces a predictable, dose-dependent metabolic acidosis that is characterised by hyperchloraemia and a decreased plasma bicarbonate concentration. This effect has been observed for over 100 years, and the occurrence of the phenomenon is not in dispute. What is refuted is the mechanism by which 0.9% NaCl administration induces metabolic acidosis. The purpose of this review is to define the mechanism for the development of hyperchloraemic acidosis, clarify methods for its clinical recognition, and develop an appropriate treatment protocol for this common iatrogenic acid-base disorder.
| Original language | English (US) |
|---|---|
| Pages (from-to) | 111-122 |
| Number of pages | 12 |
| Journal | International Journal of Intensive Care |
| Volume | 12 |
| Issue number | 3 |
| State | Published - Sep 2005 |
ASJC Scopus subject areas
- Critical Care and Intensive Care Medicine