Hypertonic saline is a negative inotropic agent in normovolumic dogs

P. D. Constable, W. W. Muir, P. F. Binkley

Research output: Contribution to journalArticlepeer-review


The inotropic effects of hypertonic saline (HS) and hyperosmotic dextrose (HD; 2,400 mosmol/l, 4 ml/kg) were determined in normovolumic, chloralose- anesthetized, intact (n = 14) and autonomically blocked (n = 8) dogs. Solutions were infused intravenously over 3 min. HS and HD rapidly increased preload in both intact and autonomically blocked dogs, as assessed by significant (P < 0.05) increases in plasma volume, end-diastolic volume, end- diastolic pressure. In intact dogs, HS produced a nonsignificant decrease in end-systolic elastance (E(es)) and a nonsignificant increase in the maximal rate of change of left ventricular pressure (dP/dt(max)) and cardiac output, whereas HD produced a significant increase in E(es), dP/dt(max), and cardiac output. In autonomically blocked dogs, HS significantly decreased E(es) and significantly increased dP/dt(max) but did not alter cardiac output, whereas HD significantly increased E(es), dP/dt(max), and cardiac output. We conclude that in normovolumic animals, HS is a negative inotropic agent, HD is a positive inotropic agent, and the in vivo effect of an ionic hyperosmotic agent (HS) differs from that of a nonionic hyperosmotic agent (HD).

Original languageEnglish (US)
Pages (from-to)H667-H677
JournalAmerican Journal of Physiology - Heart and Circulatory Physiology
Issue number2 36-2
StatePublished - 1994


  • afterload
  • cardiac contractility
  • end-systolic elastance
  • hyperosmotic dextrose
  • preload

ASJC Scopus subject areas

  • Physiology
  • Cardiology and Cardiovascular Medicine
  • Physiology (medical)


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