Hypercoagulability in Dogs with Blastomycosis

M. A. Mcmichael, M. O'Brien, S. A. Smith

Research output: Contribution to journalArticlepeer-review

Abstract

Background: Blastomycosis is a potentially fatal fungal disease that most commonly affects humans and dogs. The organism causes systemic inflammation and has a predilection for the lungs. The inflammation might lead to a hypercoagulable state with microemboli in the pulmonary circulation which could contribute to inadequate oxygen exchange in infected dogs. Hypothesis/Objectives: Dogs with blastomycosis will be hypercoagulable compared with healthy case-matched controls. Animals: Client-owned dogs with a diagnosis of blastomycosis (n = 23) and healthy case-matched controls (n = 23). Methods: Prospective case-controlled study of client-owned dogs presented to a veterinary teaching hospital with clinical signs compatible with blastomycosis. Complete blood counts, fibrinogen, PT, aPTT, thromboelastometry (TE), thrombin antithrombin complexes (TAT), and thrombin generation were evaluated. Results: Cases had a leukocytosis compared with controls [mean (SD) 16.6 (7.6) × 103/μL versus 8.2 (1.8) × 103/μL, P < .001], hyperfibrinogenemia [median 784 mg/dL, range 329-1,443 versus median 178 mg/dL, range 82-257, P < .001], and increased TAT concentrations [mean (SD) 9.0 (5.7) μg/L versus 2.0 (2.8) μg/L, P < .001]. As compared to controls, cases were also hypercoagulable as evaluated by thromboelastometry and had increased in vitro thrombin generation on calibrated automated thrombography. Conclusions and Clinical Importance: Hypercoagulability occurs in dogs with systemic blastomycosis. Additional studies are needed to explore a possible contribution of thrombogenicity to the clinical manifestations of systemic blastomycosis.

Original languageEnglish (US)
Pages (from-to)499-504
Number of pages6
JournalJournal of veterinary internal medicine
Volume29
Issue number2
DOIs
StatePublished - Mar 1 2015

Keywords

  • Canine
  • Thromboelastography
  • Thromboelastometry
  • Thrombosis

ASJC Scopus subject areas

  • veterinary(all)

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