Hyper-susceptibility to deltamethrin in parats-1 DDT resistant Drosophila melanogaster

Joao H.F. Pedra; Andrew Hostetler; Patrick J. Gaffney; Robert A. Reenan; Barry R. Pittendrigh

doi:10.1016/j.pestbp.2003.09.007

Hyper-susceptibility to deltamethrin in para^ts-1 DDT resistant Drosophila melanogaster

Joao H.F. Pedra, Andrew Hostetler, Patrick J. Gaffney, Robert A. Reenan, Barry R. Pittendrigh

Research output: Contribution to journal › Article › peer-review

Abstract

The extensively studied para gene encodes a α-subunit of the voltage-activated sodium channel in Drosophila melanogaster, which is the documented target site of DDT and pyrethroid insecticides. The para ^ts-1 fruit fly line carries a recessive sex-linked insecticide-resistance trait (para^ts-1 allele) that has been defined on the basis of the behavioral phenotype of temperature-sensitive paralysis. We have determined that para^ts-1 confers hyper-susceptibility to delta-methrin in addition to the previously annotated resistance to DDT, revealing the presence of negative cross-resistance. We investigated the potential use of negative cross-resistance shifting para^ts-1 gene frequencies in D. melanogaster populations. After five generations of selection, the para^ts-1 allele, respectively, became more or less frequent whether Drosophila populations were selected with DDT or deltamethrin.

Original language	English (US)
Pages (from-to)	58-66
Number of pages	9
Journal	Pesticide Biochemistry and Physiology
Volume	78
Issue number	1
DOIs	https://doi.org/10.1016/j.pestbp.2003.09.007
State	Published - Jan 2004
Externally published	Yes

Keywords

DDT and deltamethrin
Negative cross-resistance
Pesticide resistance
para gene

ASJC Scopus subject areas

Agronomy and Crop Science
Health, Toxicology and Mutagenesis

Online availability

10.1016/j.pestbp.2003.09.007

Library availability

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Cite this

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title = "Hyper-susceptibility to deltamethrin in parats-1 DDT resistant Drosophila melanogaster",

abstract = "The extensively studied para gene encodes a α-subunit of the voltage-activated sodium channel in Drosophila melanogaster, which is the documented target site of DDT and pyrethroid insecticides. The para ts-1 fruit fly line carries a recessive sex-linked insecticide-resistance trait (parats-1 allele) that has been defined on the basis of the behavioral phenotype of temperature-sensitive paralysis. We have determined that parats-1 confers hyper-susceptibility to delta-methrin in addition to the previously annotated resistance to DDT, revealing the presence of negative cross-resistance. We investigated the potential use of negative cross-resistance shifting parats-1 gene frequencies in D. melanogaster populations. After five generations of selection, the parats-1 allele, respectively, became more or less frequent whether Drosophila populations were selected with DDT or deltamethrin.",

keywords = "DDT and deltamethrin, Negative cross-resistance, Pesticide resistance, para gene",

author = "Pedra, {Joao H.F.} and Andrew Hostetler and Gaffney, {Patrick J.} and Reenan, {Robert A.} and Pittendrigh, {Barry R.}",

note = "Funding Information: We thank Drs. E. Eliason, B. Haubold, D. A. Hanck, M. Scharf, V. Ferris, and J. Stuart and Mr. Matt Tarver for reviewing previous versions of the manuscript. We also thank Maria Grimes for preparing Figs. 2 and 3 . This project is part of the MPRINT program and was supported by Department of Entomology funds. This is publication No. 17165, Purdue University Agricultural Experimental Station, West Lafayette, IN, USA.",

year = "2004",

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AU - Pittendrigh, Barry R.

N1 - Funding Information: We thank Drs. E. Eliason, B. Haubold, D. A. Hanck, M. Scharf, V. Ferris, and J. Stuart and Mr. Matt Tarver for reviewing previous versions of the manuscript. We also thank Maria Grimes for preparing Figs. 2 and 3 . This project is part of the MPRINT program and was supported by Department of Entomology funds. This is publication No. 17165, Purdue University Agricultural Experimental Station, West Lafayette, IN, USA.

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