Hydroxyurea inhibition of greening, macromolecule synthesis and cell division in Euglena gracilis

D. E. Buetow; J. L. Mego

doi:10.1016/0005-2787(67)90016-0

Hydroxyurea inhibition of greening, macromolecule synthesis and cell division in Euglena gracilis

Research output: Contribution to journal › Article › peer-review

Abstract

Hydroxyurea inhibits chlorophyll synthesis and cell division in heat-bleached or dark-grown Euglena gracilis. 50 % inhibition of chlorophyll synthesis occurs at 0.02-0.035 M hydroxyurea. Euglena multiplies with a normal generation time and can at least partly recover the ability to green following removal of hydroxyurea. The syntheses of chlorophyll, DNA, RNA and protein are inhibited by hydroxyurea, that of chlorophyll being the most sensitive, followed in order by DNA, RNA and protein.

Original language	English (US)
Pages (from-to)	395-401
Number of pages	7
Journal	BBA Section Nucleic Acids And Protein Synthesis
Volume	134
Issue number	2
DOIs	https://doi.org/10.1016/0005-2787(67)90016-0
State	Published - Feb 28 1967
Externally published	Yes

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abstract = "Hydroxyurea inhibits chlorophyll synthesis and cell division in heat-bleached or dark-grown Euglena gracilis. 50 % inhibition of chlorophyll synthesis occurs at 0.02-0.035 M hydroxyurea. Euglena multiplies with a normal generation time and can at least partly recover the ability to green following removal of hydroxyurea. The syntheses of chlorophyll, DNA, RNA and protein are inhibited by hydroxyurea, that of chlorophyll being the most sensitive, followed in order by DNA, RNA and protein.",

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AU - Buetow, D. E.

AU - Mego, J. L.

PY - 1967/2/28

Y1 - 1967/2/28

N2 - Hydroxyurea inhibits chlorophyll synthesis and cell division in heat-bleached or dark-grown Euglena gracilis. 50 % inhibition of chlorophyll synthesis occurs at 0.02-0.035 M hydroxyurea. Euglena multiplies with a normal generation time and can at least partly recover the ability to green following removal of hydroxyurea. The syntheses of chlorophyll, DNA, RNA and protein are inhibited by hydroxyurea, that of chlorophyll being the most sensitive, followed in order by DNA, RNA and protein.

AB - Hydroxyurea inhibits chlorophyll synthesis and cell division in heat-bleached or dark-grown Euglena gracilis. 50 % inhibition of chlorophyll synthesis occurs at 0.02-0.035 M hydroxyurea. Euglena multiplies with a normal generation time and can at least partly recover the ability to green following removal of hydroxyurea. The syntheses of chlorophyll, DNA, RNA and protein are inhibited by hydroxyurea, that of chlorophyll being the most sensitive, followed in order by DNA, RNA and protein.

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