Hydroxyurea inhibition of greening, macromolecule synthesis and cell division in Euglena gracilis

D. E. Buetow, J. L. Mego

Research output: Contribution to journalArticlepeer-review

Abstract

Hydroxyurea inhibits chlorophyll synthesis and cell division in heat-bleached or dark-grown Euglena gracilis. 50 % inhibition of chlorophyll synthesis occurs at 0.02-0.035 M hydroxyurea. Euglena multiplies with a normal generation time and can at least partly recover the ability to green following removal of hydroxyurea. The syntheses of chlorophyll, DNA, RNA and protein are inhibited by hydroxyurea, that of chlorophyll being the most sensitive, followed in order by DNA, RNA and protein.

Original languageEnglish (US)
Pages (from-to)395-401
Number of pages7
JournalBBA Section Nucleic Acids And Protein Synthesis
Volume134
Issue number2
DOIs
StatePublished - Feb 28 1967
Externally publishedYes

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