Hydroxylated 2,3-diarylindenes: Synthesis, estrogen receptor binding affinity, and binding orientation considerations

Keyphrases

• Binding Affinity 100%
• Estrogen Receptor Binding 100%
• Hydroxylated 100%
• Binding Orientation 100%
• Receptor Binding Affinity 100%
• Estrogen Receptor 80%
• Hydroxylation 60%
• Binding Site 40%
• Receptor Binding 40%
• Hydroxyl Substituent 40%
• Phenyl Ring 40%
• Electron Acceptor 20%
• High Affinity 20%
• Fluorophore 20%
• Non-specific Binding 20%
• Fold Increase 20%
• Parallelization 20%
• Hydroxyl Group 20%
• Ring Systems 20%
• Cyclization 20%
• Estradiol 20%
• Knowledge-how 20%
• Binding Assay 20%
• Diphenyl 20%
• Receptor-based 20%
• Indene 20%
• Electron Donation 20%
• Parallel Changes 20%
• D-ring 20%
• Orientation Model 20%
• Nonsteroidal Estrogens 20%
• Fluorescent Ligand 20%
• Ring Hydroxylation 20%
• Hydrogen Sites 20%
• Dihydroxyl 20%

Chemistry

• Kd 100%
• Receptor Binding Affinity 100%
• Estrogen 100%
• hydroxylation 80%
• Binding Site 40%
• Hydroxyl 40%
• Hydrogen Bonding 20%
• Cyclic Structure 20%
• Hydroxyl Group 20%
• Indene 20%
• Radiometry 20%
• Non Steroidal Estrogen 20%
• Diethylstilbestrol 20%
• Biphenyl 20%

Pharmacology, Toxicology and Pharmaceutical Science

• Estrogen Receptor 100%
• Receptor 60%
• Binding Site 40%
• Hydrogen 20%
• Hydroxyl Group 20%
• Diethylstilbestrol 20%
• Biphenyl 20%
• Indene 20%
• Estrogen 20%