Abstract
A convenient, scalable synthesis of the supramolecular building block 7-deazaguanine-based urea (DeUG) is reported. Incorporation of reactive moieties (DeUG azide 10 and alkyne 11 for copper-catalyzed azide-alkyne cycloadditions, "click chemistry") and a demonstration of transesterification (DeUG glycol, 12) highlights the versatility. X-ray structures of DeUG and a DeUG-DAN heterocomplex were obtained. K assoc for the 1.2 heterocomplex was estimated to be 2 x 10 8 M -1 in chloroform.
Original language | English (US) |
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Pages (from-to) | 61-64 |
Number of pages | 4 |
Journal | Organic Letters |
Volume | 11 |
Issue number | 1 |
DOIs | |
State | Published - Jan 1 2009 |
ASJC Scopus subject areas
- Biochemistry
- Physical and Theoretical Chemistry
- Organic Chemistry