Abstract
(Matrix Presented) Incorporation of a single hydrogen bonded β-turn mimic in the backbone of a m-phenylene ethynylene oligomer is shown to affect the thermodynamic properties of the folding reaction. Oligomers 1 and 2 both undergo solvophobic helix formation, but hydrogen bonded oligomer 1 was found to form a more stable helix with a higher tolerance to solvent denaturation than isomeric, non-hydrogen bonded oligomer 2.
| Original language | English (US) |
|---|---|
| Pages (from-to) | 4663-4666 |
| Number of pages | 4 |
| Journal | Organic Letters |
| Volume | 4 |
| Issue number | 26 |
| DOIs | |
| State | Published - Dec 26 2002 |
ASJC Scopus subject areas
- Biochemistry
- Physical and Theoretical Chemistry
- Organic Chemistry